Treatment of chronic rhinosinusitis with low-dose,long-term macrolide antibiotics: An evolving paradigm |
| |
Authors: | Umur Hatipoglu Israel Rubinstein |
| |
Institution: | (1) Department of Medicine (M/C 719), University of Illinois at Chicago, 840 South Wood Street, Room 913, 60616-7323 Chicago, IL, USA |
| |
Abstract: | The 14-membered and 15-membered ring macrolide antibiotics express immunomodulatory effects in chronic respiratory disorders
in humans that are distinct from their antimicrobial properties. These drugs downregulate the excessive immune and inflammatory
responses observed in these conditions while promoting tissue repair. To this end, chronic rhinosinusitis is characterized
by mucosal inflammation of nasal and sinus mucosa for more than 3 months and accounts for significant health care resource
allocation due to difficulties in treatment. Clinical efficacy of macrolide antibiotics as biologic response modifiers in
patients with chronic rhinosinusitis is suggested by compelling basic research and small, uncontrolled clinical studies. Hence,
long-term, prospective double-blind placebo-controlled clinical studies are indicated to establish the utility of these drugs
in the treatment of patients with chronic rhinosinusitis. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|