母血、脐血和羊水中儿茶酚胺水平的测定及其临床意义

采用高效液相色谱技术测定了孕产妇血浆、胎儿血浆和羊水儿茶酚胺（ＣＡ）。结果表明：妊娠期母血ＣＡ中肾上腺素（Ｅ）和多巴胺（ＤＡ）与非孕妇女相比差异无显著意义（Ｐ＞０．０５），而去甲肾上腺素（ＮＥ）较非孕妇女明显降低（Ｐ＜０．０５）；阴道分娩产妇ＣＡ明显高于非孕和妊娠晚期妇女（ｐ＜０．０１）。正常足月胎儿脐动脉血ＮＥ、Ｅ及ＤＡ分别较脐静脉血的ＮＥ、Ｅ及ＤＡ增高３．３、４．７和２．１倍。剖宫产儿脐动脉血ＮＥ、Ｅ明显低于正常分娩儿，ＤＡ差异无显著意义。胎儿窘迫时脐动脉血浆ＣＡ较正常分娩儿明显增加，以ＮＥ、Ｅ最明显。羊水中ＣＡ伴随妊娠的进展而增加，胎儿窘迫时明显增加，超过正常范围上限者新生儿窒息发生率为６０％。

Determination catecliolamines levels in ammiotic fluid, maternal and umbilical blood

atecholamines (CA) levels of amniotic fluid,maternal and umbilical blood were determined byHPLC. The results showed that epinaphrine (E) anddopamine (DA) levels of pregnancy were significantlydifferent as compared with non-pregnant women(P>0.05), where as norepinephrine (NE) levels weresignificantly decreased (P<0.05). In vaginal delivery,CA levels of pregnant women were significantly hight-er than those of non and late-pregnant women(P<0.01). Plasma CA levels of umbilical artery werehigher than those of umbilical vein (P<0.001); NEof CA was 3.3 times, E 4.7 times and DA 2.1 times.NE and E levels of umbilical artery in cesarean sec-tion were significantly lower than those of in vaginaldelivery. In fetal distress, plasma NE and E levels ofumbilical artery were higher significantly than thoseof the normal fetus. CA levels of amniotic fluid in-creased with advance of gestational weeks,significantly in fetal distress, even more than the up-per limit of 95%. The incidence of newborn asphyxiawas about 60.0%.