胃癌组织中表皮生长因子及其受体的测定

用免疫组化ＡＢＣ法检测１０４例胃癌组织中表皮生长因子（ＥＧＦ）和表皮生长因子受体（ＥＧＦＲ），结果ＥＧＦ、ＥＧＦＲ及ＥＧＦ与ＥＧＦＲ同步表达的阳性率分别为３５．６％、４２．３％和３０．８％，阳性者多为进展期、分化不良型、ＢｏｒｒｍａｎｎＩＩＩ、ＩＶ型、硬癌型、侵犯浆膜和胃周淋巴结转移的胃癌病人；ＥＧＦ阳性病人术后１、３、５年生存率均明显低于阴性组（Ｐ＜０．０５），尤以ＥＧＦ及其受体同步表达者预后最差，均于４年内死亡。提示ＥＧＦ和ＥＧＦＲ可作为胃癌生物学恶性程度的一个标志和估价病人预后的指标。

Clinical stuily ou epidermal growth factor and itsmeptor in human gastric cancer

e detecte the expression of epidernial growthfactor (EGF) and epidennal growth factor receptor(EGFR) in 104 specimens of gastric cancer by avidinbiotinperoxides complex technique (ABC). The posi-tive rates of EGF, EGFR and synchronous EGF andEGFR were 35.6%, 42.3%, 30.8% respotively. Thepositive expression of EGF and EGFR to gastric can-cer tissue was inclined to occur in patients who were inadvaneed stages, of poorlyedifferentiated types.Bornann III,IV types, scirrhous type, seroinvasivetype or lymph node metastasic types. The survial ratesat 1,3,5 years after gastrectomy in the patients withexpression of EGF were significantly lower than thesurvival rates of the patients with negative expression(P<0.05). The patients with synchronous expressionof EGF and EGFR had the woret prognosis. Aftergastrectomy, all of theni died within 4 years. It is indi-cated that EGF and EGFR could serve as biologicalindicators of gastric cancer malignancy and an indexfor evaluating, the prognosis of the patients with gas-tric caneer.