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The effect of cimetidine treatment on suppressor T cells in duodenal ulcer patients |
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| Authors: | H Tchórzewski K Markiewicz P Malec |
| Affiliation: | Institute of Molecular Genetics, Czechoslovak Academy of Sciences, 142 20 Prague 4, Czechoslovakia |
| Abstract: | Changes in the suppressor T-lymphocyte activity were studied in 11 patients with duodenal ulcer during treatment with cimetidine. The drug was administered intravenously in a dose of 200 mg four times a day for a fortnight. Suppressor T-cell activity was determined by the Shou et al. method using two-stage culture before treatment, after 4 days of the treatment, just before drug withdrawal, and 2 days and 2 wk after the treatment. Suppressor T-cell activity significantly decreased soon after starting the treatment, remained low throughout the treatment, and rapidly and significantly increased following drug withdrawal. |
| Keywords: | mAb monoclonal antibody HSA human serum albumin PBS phosphate buffered saline, pH 7.2 SwAM swine antibody against mouse immunoglobulin SDS sodium dodecylsulphate SDS-PAGE polyacrylamide gel electrophoresis in the presence of SDS tubulin human serum monoclonal antibody |
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