| 锌指蛋白A20对Toll样受体信号途径的负反馈调控及其对机体的保护作用 |
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| 引用本文： | 黄日红,曲鹏.锌指蛋白A20对Toll样受体信号途径的负反馈调控及其对机体的保护作用[J].国际免疫学杂志,2009,32(4):294-297. |
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| 作者姓名： | 黄日红 曲鹏 |
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| 作者单位： | 1. 中心,ICU,大连医科大学附属第一医院,116011
2. 大连医科大学附属第二医心内科 |
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| 摘 要： | Toll样受体（TLR）能够识别病原体，并在病原体入侵机体的早期启动固有免疫，促进免疫细胞成熟分化及调节免疫应答，触发炎症反应。脂多糖（LPS）激活TLR4的信号转导通路后导致NF—κB和JNK／SAPK激活，使炎症因子大量表达，导致全身炎症反应和多器官功能衰竭的发生。A20作为一种NF—κB依赖性表达的胞质蛋自，对NF—κB活性有负反馈调控作用，参与了体内炎症反应的调节和凋亡抑制，对机体起到保护作用。
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| 关 键 词： | A20 Toll样受体 负反馈调控 |
Protective effects of feedback control on TLR signaling pathway by zinc finger protein A20 |
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| Institution: | HUANG Ri-hong. (Central Intensive Care Unit, The First Hospitol Affiliated to Dalian Medical University, Dalian Liaoning 11601l, China) |
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| Abstract: | Toll-like receptors (TLRs) recognize pathogens and initiate innate immune responses at the early stage of virus invasion, promoting the maturation and differentiation of immune cells, regulating immune respon-ses,and triggering inflammatory responses. Lipopolysaccharide (LPS) activates the TLR4 signaling pathways which result in the activation of NFκB and JNK/SAPK and the expression of large amounts of inflammatory fac-tors,leading to systemic inflammatory response and multiple organ failure. A20, a NFκB-dependant cytosolic protein, via a negative feedback loop blocks NFκB activation and participates in the regulation of inflammatory responses and the inhibition of apptosis;therefore, it provides protective effect on the body. |
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| Keywords: | A20 |
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