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Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals
Authors:K. S. Burgdorf  A. P. Gjesing  N. Grarup  J. M. Justesen  C. H. Sandholt  D. R. Witte  T. J?rgensen  S. Madsbad  T. Hansen  O. Pedersen
Affiliation:(1) The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Room 1.1.N121, DK-2100 Copenhagen, Denmark;(2) Hvidovre University Hospital, Copenhagen, Denmark;(3) Steno Diabetes Center, Copenhagen, Denmark;(4) Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark;(5) Institute of Biomedical Science, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark;(6) Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark;(7) Faculty of Health Science, University of Aarhus, Aarhus, Denmark;(8) Hagedorn Research Institute, Gentofte, Denmark
Abstract:

Aims/hypothesis  

Genome-wide association studies have identified novel WHR and BMI susceptibility loci. The aim of this study was to elucidate if any of these loci had an effect on quantitative measures of glucose homeostasis, including estimates of insulin release and insulin sensitivity in an epidemiological setting.
Keywords:
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