Novel human topoisomerase I inhibitors, topopyrones A, B, C and D. II. Structure elucidation |
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Authors: | Ishiyama D Kanai Y Senda H Iwatani W Iwatani W Konno H Kanazawa S |
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Institution: | Metabolism Research, Kaken Pharmaceutical Co., Ltd., Fujieda, Shizuoka, Japan. |
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Abstract: | The structures of novel topoisomerase I inhibitors, topopyrones A, B, C and D were elucidated by spectral analysis of the chemical derivatives. These compounds are an anthraquinone type containing a fused 1,4-pyrone moiety. Topopyrones A and B contain a chlorine atom, however C and D do not. It was suggested that topopyrones B and D are converted from topopyrones A and C, respectively by Wessely-Moser type rearrangement. |
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