移居4300m居住不同时间尿生化指标的变化

目的:探讨移居高原居住不同时间尿生化指标的变化。方法:对移居海拔4 300 m高原3个月(103人)、6个月(70人)及1年(106人)的男性汉族健康青年,采用自动尿分析仪进行晨尿11项指标分析。结果:移居高原者尿11项指标均有异常出现,主要以尿蛋白、尿潜血、白细胞居多。尿蛋白、尿潜血和白细胞在移居高原3个月较6个月和1年以上的阳性率均增高(P<0.01或0.05);6个月与1年以上比较无统计学意义(P>0.05)。结论:高原低氧环境对肾脏的损害是随着居住时间的延长而减弱。低氧导致肾小管重吸收功能降低和肾小球透性增强。

Changes of biochemical indexes in urine of migrants at 4 300 m altitude

Objective:To explore the changes of biochemical indexes in urine of migrants living at high altitude for different times.Methods:11 biochemical indexes in urine of 103 migrants having lived at 4 300 m altitude for 3 months,of 70 ones having lived at 4 300 m altitude for 6 months and of 106 ones having lived at 4 300 m altitude for 12 months.Results:All of these 11 indexes were abnormal,especially protein,occult blood and white cell.The levels of protein,occult blood and white cell in urine of the subjects living for 3 months were higher than those in urine of the subjects living for 6 months and 12 months(P<0.01 or 0.05).But the difference of above indexes between living for 6 months and 12 months was not significant(P>0.05).Conclusion:Hypoxic environment may weaken the re-absorption of renal tubule and enhance glomerulus's permeability,but these effects of hypoxia on the renal function will become weaker as migrants live at high altitude longer.