与高龄妊娠相关的几种胎儿疾病

高龄妊娠是指孕妇年龄在预产期满35周岁的妊娠，对妊娠和围产儿结局产生重要影响。目前已知高龄妊娠显著增加胎儿染色体畸变的发生，高龄妊娠与胎儿非染色体异常畸形、生长受限等胎儿发育异常相关，加强高龄妊娠相关的胎儿疾病筛查、诊断和处理对降低出生缺陷发生率和围产儿死亡率具有重要意义。

Several fetal abnormalities associated with advanced maternal age

Advanced maternal aged pregnancy (AMAP) is usually defined as pregnancy at the age of 35 years and older, which has been found to be associated with numerous adverse maternal and perinatal outcomes. The AMAP is not only related with the increasing number of fetal chromosome aberration, but also relate with fetal non-chromosomal anomalies and fetal growth retardation. Strengthening the prenatal screening, diagnosis and management of the AMAP associated fetal abnormalities has great significance for reducing the occurrence of birth defects and perinatal mortality.