Natural human antibody responses to Plasmodium vivax apical membrane antigen 1 under low transmission and unstable malaria conditions in Sri Lanka |
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| Authors: | Wickramarachchi Thilan Premaratne Prasad H Perera K L R Lakshman Bandara Sumith Kocken Clemens H M Thomas Alan W Handunnetti Shiroma M Udagama-Randeniya Preethi V |
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| Affiliation: | Department of Zoology, Faculty of Science, University of Colombo, Colombo 3, Sri Lanka. |
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| Abstract: | Plasmodium vivax apical membrane antigen 1, an important malaria vaccine candidate, was immunogenic during natural malaria infections in Sri Lanka, where low transmission and unstable malaria conditions prevail. Antibody prevalence increased with exposure in areas where malaria was or was not endemic. A marked isotype switch to cytophilic (immunoglobulin G1 [IgG1]/IgG3) antibodies was evident with increasing exposure exclusively in residents from areas of endemicity. |
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