应用内中膜厚度及动脉僵硬度定量检测技术评价高血压患者颈动脉弹性

目的 探讨内中膜厚度(QIMT)及动脉僵硬度(QAS)测量技术评价高血压患者颈动脉弹性功能的临床价值.方法 原发性高血压患者137例,按有无斑块形成分为高血压无斑块组(63例)及高血压斑块组(74例),并与87例正常人相对照.应用QIMT软件描记颈动脉内中膜厚度(IMT),QAS软件测量颈动脉内径(d)、扩张度(e)、弹性系数(α)、弹性系数(β)、僵硬度系数(CC)、脉搏波传播速度(PWV)及压力局部收缩压(LOCPsys)等,分析三组上述指标的差别、与血压的关系及弹性指标之间的相关性.结果 随颈动脉壁病变的加重,高血压组颈动脉IMT、d、α、β、PWV、LOCPsys逐渐升高,CC逐渐降低;两侧颈动脉弹性指标之间存在差异.α、β、PWV OR值较大,β OR值最大.IMT、e、α、β、PWV、LOCPsys同收缩压和脉压呈正相关,CC与之呈负相关;颈动脉弹性指标间相关性很大.结论 随高血压颈动脉壁病变的加重,颈动脉IMT逐渐增厚,弹性减低;应用QIMT和QAS技术能准确评价颈动脉弹性.

Abstract：

Objective To explore the value of quantivtative intima-media thickness(QIMT) and quantitative arterial stiffness (QAS) technique on evaluating the elasticity of carotid artery in patients with essential hypertension.Methods One hundred and thirty-seven patients with primary hypertension were divided into two groups according with or without atherosclerotic plaques:hypertensive group without plaque (63 cases) and hypertensive group with plaque (74 cases),and 87 healthy aged subjects were selected as the control group.The intima media thickness (IMT) was tracted with QIMT software.The internal diameter (d),expansion (e),elastic coefficient α and β,compliance coefficient (CC),pulse wave velocity (PWV) and local systolic pressure (LOCPsys) were measured with QAS software.The differences of the parameters among the groups,and the relation with pressure and the correlation between the elastic indexs were analyzed.Results IMT,d,α,β,PWV and LOCPsys in hypertensive group increased,and CC decreased gradually with the lesion development of carotid aterial wall.There was difference in elastic indexs between the left and right carotid.The OR of α,β,PWV was comparatively large and the OR of β was the largest.There was positive relevance between the indexs of IMT,e,α,β,PWV,LOCPsys and systolic blood pressure and pulse pressure,and there was negative correlation between CC and systolic blood pressure and pulse pressure.The relevance between the elastic indexs was large.Conclusions The intima-media thickness of carotid increased gradually,and the elasticity decreased with the lesion development of carotid aterial wall in patients with hypertension.It can evaluate the arterial elasticity accurately and quantitavely using the QIMT and QAS technique.

Evaluation of carotid artery elasticity in patients with hypertension using quantitative intima-media thickness and quantitative arterial stiffness technique

Objective To explore the value of quantivtative intima-media thickness(QIMT) and quantitative arterial stiffness (QAS) technique on evaluating the elasticity of carotid artery in patients with essential hypertension.Methods One hundred and thirty-seven patients with primary hypertension were divided into two groups according with or without atherosclerotic plaques:hypertensive group without plaque (63 cases) and hypertensive group with plaque (74 cases),and 87 healthy aged subjects were selected as the control group.The intima media thickness (IMT) was tracted with QIMT software.The internal diameter (d),expansion (e),elastic coefficient α and β,compliance coefficient (CC),pulse wave velocity (PWV) and local systolic pressure (LOCPsys) were measured with QAS software.The differences of the parameters among the groups,and the relation with pressure and the correlation between the elastic indexs were analyzed.Results IMT,d,α,β,PWV and LOCPsys in hypertensive group increased,and CC decreased gradually with the lesion development of carotid aterial wall.There was difference in elastic indexs between the left and right carotid.The OR of α,β,PWV was comparatively large and the OR of β was the largest.There was positive relevance between the indexs of IMT,e,α,β,PWV,LOCPsys and systolic blood pressure and pulse pressure,and there was negative correlation between CC and systolic blood pressure and pulse pressure.The relevance between the elastic indexs was large.Conclusions The intima-media thickness of carotid increased gradually,and the elasticity decreased with the lesion development of carotid aterial wall in patients with hypertension.It can evaluate the arterial elasticity accurately and quantitavely using the QIMT and QAS technique.