帕罗西汀治疗广泛性焦虑症

目的 :探讨帕罗西汀对广泛性焦虑症的疗效和副作用。方法 :帕罗西汀组 30例 ,男性 12例 ,女性 18例 ,予帕罗西汀 2 0～ 4 0mg·d- 1,po ;苯二氮类组 30例 ,男性 13例 ,女性 17例 ,其中 16例予阿普唑仑 0 .4～ 0 .8mg ,po ,2～ 3次·d- 1,14例予氯硝安定 1～ 2mg ,po ,2～ 3次·d- 1;安慰剂组 30例 ,男性 11例 ,女性 19例 ,给予安慰剂 1片 ,po ,tid。疗程均为 12wk ,治疗前及治疗wk 2 ,4 ,8,12末采用HAMA ,SAS ,CGI ,TESS评定疗效及副作用。结果 :帕罗西汀组显效率 90 % ,苯二氮类组显效率 50 % ,经Ridit分析 ,P <0 .0 1。帕罗西汀组常见副作用有口干、便秘、恶心等 ,不影响治疗。结论 :帕罗西汀长期治疗广泛性焦虑症疗效确切 ,副作用轻微。

Paroxetine in treatment of generalized anxiety

AIM: To investigate the clinical effect and side-effects of paroxetine in the treatment of generalized anxiety (GA). 　METHODS: Ninety patients who met Chinese classification and diagnostic criteria of mental disorders, 2nd Rev Ed (CCMD-2-R) criteria for GA were randomly divided into paroxetine group of 30 patients (M 12, F 18; age 40 a±s 13 a) which was treated with paroxetine 20-40 mg, po, qd or bid, benzodiazepines group of 30 patients (M 13, F 17; age 37 a±13 a) among them, 16 patients were treated with alprazolam 0.4-0.8 mg, po, bid or tid, 14 patients were treated with clonazepam 1-2 mg, po, bid or tid and placebo group of 30 patients (M 11, F 19; age 37 a±13 a) which was treated with placebo 1 tablet, tid for 12 wk. Effects were evaluated with Hamailton anxiety scale (HAMA), self-rating anxiety scale (SAS), clinical global impression scales (CGI) and treatment emergent symptoms scale (TESS), before and after the wk 2,4,8,12 of treatment.　RESULTS: The excellent response rates of paroxetine group and benzodiazepines group were 90 % and 50 % (P<0.01). The side-effects of paroxetine group were dry mouth, constipation, nausea, but those were less than that of benzodiazepines group. 　CONCLUSION: The study suggests that paroxetine is an effective drug for the long treatment of GA and the side-effect is less.