冠心病患者活性肽Intermedin水平及临床意义

目的测定冠心病患者血浆Intermedin（IMD）浓度，探讨活性肽IMD与冠状动脉粥样硬化、冠心痛的关系以及临床意义。方法随机选取冠心病患者58例，根据冠状动脉造影结果，按冠状动脉狭窄的程度分4组；按狭窄的血管支数分为单支组、双支组、多支组、0支组。随机选取同期查体健康者22例作为对照，年龄（56．36±9．72）岁。采用同批酶联吸附法测定血浆IMD浓度。应用SPSS11．5进行数据统计分析。结果冠心痛组血浆IMD水平（2．56±0．78mg／L）明显高于对照组（1．85±0．31）mg／L（P〈0．01）；不同狭窄程度冠状动脉病变的组间血浆IMD水平有显著差异（P〈0．01）；冠状动脉狭窄不同支数组间血浆IMD水平无显著差异（P=0．27）。结论随冠状动脉病变程度加重，冠心病患者血浆IMD水平出现升高幅度降低，与冠状动脉病变支数无关。

Study on the Plasma Concentration of Intermedin in Patients with Coronary Heart Disease

Objective To determine the plasma concentration of intermedin in patients with coronary heart disease（CHD） so as to discover the relationship between cardiovascular active peptides intermedin and CHD as well as its clinical significance. Methods Fifty-eight patients with CHD （ 34 men and 24 women, mean age 61.93 ± 9.96 years） met the diagnostic criteria for ischemic heart disease. They were divided into different subsets according to SCAG. Twenty-two healthy individuals （ 13 men and 9 women, mean age 56.36 ± 9.72 years） were chosen as control group. Peripheral venous blood samples were collected in the morning. The plasma concentration of intermedin was detected with enzyme linked immun absorpsion assay （ELISA）. All data was analyzed with t-test and analysis of variance （ANOVA）. Results The plasma concentration of intermedin in the CHD group was significantly higher than those in control group （2.56± 0. 78mg/L, 1.85±0.31mg/L,P 〈0.01）. There was statistical significance among different degree subsets of coronary artery stenosis in the plasma concentration of intermedin（ F = 7. 931 ,P 〈 0.01 ）. There was no statistical significance among different branches of coronary artery stenosis in the plasma concentration of intermedin （ F = 1.37, P = 0.27 ）. Conclusion The plasma concentration of intermedin of CHD were significantly higher than that of the control group. The plasma concentration of intermedin in different degree subsets of coronary artery stenosis was gradualy decreasing with the coronary artery stenosis degree increasing. It has no relation to the number of the branches of coronary artery stenosis.