超短期他汀类药物治疗对非ST段抬高型急性冠脉综合征患者冠状动脉介入治疗术后再灌注及短期预后的影响

目的探讨冠状动脉介入治疗(PCI)术前超短期应用他汀类药物对非ST段抬高型急性冠脉综合征(NSTE-ACS)患者心肌再灌注及短期预后的影响。方法将入院后72h内接受PCI的162例NSTE-ACS高危患者随机分为强化他汀治疗组和标准剂量他汀治疗组,于PCI术前服用辛伐他汀3d,观察PCI术前、术后即刻靶血管心肌梗死溶栓试验(TIMI)血流分级和心肌呈色分级(MBG)的差异,以及PCI术后24h肌酸激酶同工酶(CK-MB)的变化、PCI术后1个月心功能和主要心脏不良事件(MACE)的发生情况。结果两组间基础临床资料比较差异无统计学意义(P<0.05)。PCI术前强化组靶血管TIMI血流2～3级和MBG2～3级的比例显著高于标准组,差异有统计学意义(P<0.05)。PCI术后两组靶血管TIMI血流3级比例差异无统计学意义(P>0.05),强化组靶血管MBG2～3级的比例显著高于标准组,差异有统计学意义(P<0.05)。强化组CK-MB增高比例显著低于标准组,差异有统计学意义(P<0.05)。PCI术后1个月强化组左心射血分数(LVEF)为(0.58±0.09)%,明显好于标准组(0.53±0.08)%,差异有统计...

Effects of Short-Term Statins Pre-treatment on Reperfusion and Short-Term Clinical Prognosis after Percutanous Coronary Intervention in Patients with Non ST-segment Elevation Acute Coronary Syndrome

Objective To evaluate the effect of short-term pre-treatment with statins on the reperfusion and short-term clinical prognosis in patients with non ST-segment elevation acute coronary syndrome(NSTE-ACS) who underwent successful primary percutanous coronary intervention (PCI).Methods A total of 162 consecutive high-risk NSTE-ACS patients undergoing PCI within 72 hours were randomly divided into two groups:standard statin group received 20 mg simvastatin and intensive statin group received 80 mg simvastatin f...