| 2型糖尿病合并非酒精性脂肪肝与胰岛素抵抗及心血管病变发生的关系研究 |
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| 引用本文： | 范慧,张鹏睿,徐援.2型糖尿病合并非酒精性脂肪肝与胰岛素抵抗及心血管病变发生的关系研究[J].中国全科医学,2011,14(2). |
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| 作者姓名： | 范慧 张鹏睿 徐援 |
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| 作者单位： | 首都医科大学附属北京朝阳医院内分泌科,北京市,100020 |
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| 摘 要： | 目的探讨2型糖尿病(T2DM)患者发生非酒精性脂肪肝(NAFLD)的相关因素及其与胰岛素抵抗、心血管病变发生的关系。方法回顾性分析838例住院T2DM患者的一般资料、实验室检查结果,根据B超检查结果诊断NAFLD。比较T2DM合并NAFLD者与T2DM未合并NAFLD者的基本资料、胰岛功能、血脂水平及并发症、合并症发生情况。结果住院T2DM患者中,442例(52.7%)未合并NAFLD(A组),396例(47.3%)合并NAFLD(B组)。与A组比较,B组患者丙氨酸氨基转移酶(ALT)、谷氨酰转酞酶(γ-GT)水平显著升高而AST/ALT显著降低;血清三酰甘油(TG)水平显著升高而高密度脂蛋白胆固醇(HDL-C)水平显著降低;胰岛素及C肽曲线下面积、胰岛素分泌指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)显著增大;合并脑血管病变、糖尿病足、冠心病、高血压、代谢综合征、颈动脉或双下肢动脉粥样硬化的发生率均显著增高,上述差异均有统计学意义(P<0.05)。Lo-gistic回归分析显示,体质指数(BM I)、腰臀比、TG、合并代谢综合征、ALT、HOMA-IR、胰岛素曲线下面积是NAFLD发生的独立危险因...
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| 关 键 词： | 糖尿病 2型 非酒精性脂肪肝 胰岛素抵抗 心血管疾病 |
Relationship between Non-alcohol Fatty Liver Disease and Insulin Resistance/Cardiovascular Diseases in Patients with Type 2 Diabetes Mellitus |
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| FAN Hui,ZHANG Peng-rui,XU Yuan.Relationship between Non-alcohol Fatty Liver Disease and Insulin Resistance/Cardiovascular Diseases in Patients with Type 2 Diabetes Mellitus[J].Chinese General Practice,2011,14(2). |
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| Authors: | FAN Hui ZHANG Peng-rui XU Yuan |
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| Institution: | FAN Hui,ZHANG Peng-rui,XU Yuan.Department of Endocrinology,Beijng Chaoyang Hospital,Capital University of Medical Sciences,Beijing 100020,China |
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| Abstract: | Objective To explore factors that influence the occurrence of non-alcohol fatty liver disease(NAFLD) in patients with type 2 diabetes mellitus(T2DM) and the relationship between NAFLD and insulin resistance/cardiovascular diseases(CVD).Methods The general data and laboratory test results of 838 T2DM in-patients were analyzed retrospectively,while NAFLD was diagnosed according to ultrasound findings.The general data,functions of pancreatic islet,lipid levels,and complications/comorbilities were compared betw... |
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| Keywords: | Diabetes mellitus type 2 Non-alcoholic fatty liver disease Insulin resistant Cardiovascular Diseases |
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