| 百草枯中毒肺纤维化患者血清基质金属蛋白酶及其抑制剂水平的变化 |
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| 引用本文： | 杨润秀,陈进玲,刘志宁.百草枯中毒肺纤维化患者血清基质金属蛋白酶及其抑制剂水平的变化[J].中国全科医学,2011,14(2). |
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| 作者姓名： | 杨润秀 陈进玲 刘志宁 |
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| 作者单位： | 河北省唐山市工人医院急诊内科,063000 |
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| 摘 要： | 目的探讨血清基质金属蛋白酶-9(MMP-9)、金属蛋白酶组织抑制剂-1(TIMP-1)在百草枯(PQ)中毒肺纤维化患者中的动态变化。方法 30例健康对照组于受检时,30例PQ中毒患者于入院时及入院后7 d、14 d、28 d抽取静脉血,采用酶联免疫吸附法(ELISA)检测血清MMP-9和TIMP-1的水平。结果 PQ中毒患者入院时、入院后7 d、14 d血清MMP-9水平较对照组明显升高,差异有统计学意义(P<0.05)。PQ中毒患者入院后7d血清MMP-9水平较入院时及入院后14 d均明显升高,差异有统计学意义(P<0.05),PQ中毒患者血清MMP-9水平于入院后7 d达高峰。PQ中毒患者入院后7 d、14 d、28 d血清TIMP-1水平较对照组明显升高,差异有统计学意义(P<0.05)。PQ中毒患者入院后14 d血清TIMP-1水平较入院后7 d明显升高,差异有统计学意义(P<0.05),PQ中毒患者血清TIMP-1水平于入院后14 d达高峰。结论 MMP-9和TIMP-1在PQ中毒肺纤维化的发病机制中起重要作用。
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| 关 键 词： | 百草枯 中毒 肺纤维化 明胶酶B |
Changes of Serum Matrix Metalloproteinase-9 and Its Inhibitor in Patients with Pulmonary Fibrosis due to Paraquat Poisoning |
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| YANG Run-xiu,CHEN Jin-ling,LIU Zhi-ning.Changes of Serum Matrix Metalloproteinase-9 and Its Inhibitor in Patients with Pulmonary Fibrosis due to Paraquat Poisoning[J].Chinese General Practice,2011,14(2). |
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| Authors: | YANG Run-xiu CHEN Jin-ling LIU Zhi-ning |
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| Abstract: | Objective To explore the dynamic changes of serum matrix metalloproteinase-9(MMP-9)and metalloproteinase-1 inhibitor(TIMP-1) in patients with pulmonary fibrosis(PF) due to paraquat(PQ) poisoning.Methods Venous blood was drawn in 30 healthy subjects at medical examination,30 PQ poisoning patients at admission,on days 7,14,28 after admission,and levels of serum MMP-9 and TIMP-1 were detected by enzyme linked immunosorbent assay(ELISA).Results Serum MMP-9 level was significantly higher in PQ poisoning patients... |
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| Keywords: | Paraquat Poisoning Pulmonary fibrosis Gelatinase B |
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