Investigation of human papillomavirus DNA in colorectal carcinomas and adenomas |
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| Authors: | Dilek Yavuzer Nimet Karadayi Taflan Salepci Huseyin Baloglu Resat Dabak Oya Uygur Bayramicli |
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| Affiliation: | (1) Department of Pathology, Dr. Lutfi Kirdar Kartal Training and Research Hospital, 34865 Cevizli/Istanbul, Turkey;(2) Department of Oncology, Dr. Lutfi Kirdar Kartal Training and Research Hospital, 34865 Cevizli/Istanbul, Turkey;(3) Department of Pathology, Gulhane Medical Academy, Haydarpasa Training Hospital, 34668 Kadikoy/Istanbul, Turkey;(4) Department of Family Medicine, Dr. Lutfi Kirdar Kartal Training and Research Hospital, 34865 Cevizli/Istanbul, Turkey;(5) Department of Gastroenterology, Maltepe University Medical School, 34848 Maltepe/Istanbul, Turkey |
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| Abstract: | Human papillomavirus (HPV) has been considered to be an etiological agent for anogenital cancers, such as cervical cancer and possibly a subset of cancers of the aerodigestive tract. The aim of the study was to evaluate the presence of human papillomavirus DNA in colorectal carcinomas and adenomas. Formalin-fixed and paraffin-embedded archival tissue samples were used for DNA extraction. One hundred and six colorectal carcinomas and 62 adenomas were screened by nested polymerase chain reaction (PCR) for HPV DNA with a control group of 49 cervical tissues with invasive cervical carcinoma and cervical intraepithelial neoplasia (CIN). In the study group, we did not find HPV DNA positivity in any of all the colorectal carcinomas and adenomas. In the control group with cervical lesions, 34 out of 49 (69.4%) samples were positive for the HPV DNA. These results indicated that there was no correlation between HPV infection and colorectal carcinomas and adenomas. |
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