| 辽宁地区FoxO1基因rs17446593多态性与2型糖尿病的关系 |
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| 引用本文： | 王玉霞,刘迪杰,吴志香,边澈,索琳娜,刘畅,韩玲玲.辽宁地区FoxO1基因rs17446593多态性与2型糖尿病的关系[J].医学临床研究,2014(3):417-419. |
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| 作者姓名： | 王玉霞 刘迪杰 吴志香 边澈 索琳娜 刘畅 韩玲玲 |
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| 作者单位： | [1]中国医科大学附属第四医院内分泌科,辽宁沈阳110032 [2]中国医科大学附属第四医院生物治疗科,辽宁沈阳110032 [3]辽宁中医药大学附属医院内分泌科,辽宁沈阳110032 |
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| 基金项目： | 辽宁省科技厅资助项目（2012225019） |
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| 摘 要： | 【目的】探讨FoxO1基因rs17446593单核苷酸多态性与2型糖尿病（T2DM ）的关系。【方法】395例T2DM患者和366例对照组，用分子量阵列技术（MassARRAY）方法检测FoxO1基因 rs17446593单核苷酸多态性，并用SPSS13．0统计软件进行分析。【结果】FOXO1基因 rs17446593在 T2DM 组GG、GA 型及AA型分别为1．77％、27．09％及71．14％，在对照组GG、GA型及AA型分别为1．64％、20．22％及78．14％（两组间χ2＝5．0460，P ＝0．080）。G等位基因在两组分别为15．32％，及11．75％（两组间χ2＝4．116，P ＝0．042）。【结论】FoxO1基因 rs17446593 G等位基因可能是T2DM的易感基因。
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| 关 键 词： | 糖尿病 2型 多态现象 遗传 辽宁 |
Correlation Between FoxO1 Gene rs17446593 Polymorphism and Type 2 Diabetes Mellitus in Li-aoning Province |
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| Institution: | WANG Yu-xia , LIU Di-jie , WUZhi-xiang ,et al (Department of Endocrinology, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China) |
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| Abstract: | Objective]To explore the correlation between FOXO1 gene rs17446593 polymorphism and type 2 diabetes mellitus（T2DM ） .Methods] A total of 395 patients with T2DM and 366 control subjects were chosen .MassARRAY method was used to determine FOXO1 gene rs17446593 polymorphism .SPSS13 .0 sta-tistical software was used for the analysis .Results] The frequencies of genotype GG ,GA and AA of FOXO1 gene rs17446593 in T2DM group were 1 .72% ,27 .09% and 71 .14% ,respectively ,and those in control group were 1 .64% ,20 .22% and 78 .14% ,respectively （χ2 = 5 .0460 ,P =0 .080 between two groups） .The fre-quencies of G allele in two groups were 15 .32% and 11 .75% ,respectively （χ2 =4 .116 ,P =0 .042 between two groups） .Conclusion]Allele G of FOXO1 gene rs17446593 may be the predisposing gene of T2DM . |
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| Keywords: | Diabetes Mellitus Type 2 Polymorphism Genetic LIAONING |
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