季节性变应性鼻炎患者血清白三烯 E4及肿瘤坏死因子水平的测定及意义 |
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引用本文: | 张波,李洁,王普艳,郭燕冰,许继宗,李玉华. 季节性变应性鼻炎患者血清白三烯 E4及肿瘤坏死因子水平的测定及意义[J]. 医学临床研究, 2014, 0(3): 540-542 |
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作者姓名: | 张波 李洁 王普艳 郭燕冰 许继宗 李玉华 |
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作者单位: | 解放军306医院中医科,北京100101 |
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摘 要: | 【目的】探讨季节性变应性鼻炎(SAR)与血清白三烯E4(LTE4)及肿瘤坏死因子(TNF-α)水平的变化及临床意义。【方法】选择符合S A R标准的患者40例作为观察组,同时选取40例正常人作为对照组,分别在春、夏、秋、冬四个季节进行一次血清LTE4、TNF-α水平的检测。【结果】观察组血清LTE4、TNF-α水平在春、冬季较对照组均有显著增高,且两组相比较差异均有显著性(P<0.01或 P<0.05),而两组在夏、秋季血清LTE4、TNF-α水平相比较无统计学意义(P>0.05)。且血清LTE4与TNF-α无明显相关性。【结论】血清LTE4、TNF-α通过参与局部炎症反应,在SAR发病过程中起到较重要的作用,在临床的预防及诊治中有较大的参考价值。
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关 键 词: | 鼻炎 ,变应性 ,季节性 血液 白三烯E4 血液 肿瘤坏死因子α 血液 |
Detection and Analysis of Leukotriene E4 and Tumor Necrosis Factor of Patients with Seasonal Allergic Rhinitis |
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Affiliation: | ZHANG Bo, LI Jie, WANG Pu-yan,et al (Department of Traditional Chinese Medicine, No. 306 Hospital of PLA , Beijing 100101, China ) |
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Abstract: | [Objective] To explore changes and clinical significance of leukotriene E 4(LTE4) and tumor necrosis factor-alpha(TNF-α) in seasonal allergic rhinitis(SAR) .[Methods] Totally 40 patients who met the SAR diagnosis standard were regarded as observation group ,while 40 healthy people were regarded as control group .Serum levels of LTE4 and TNF-αin each season were detected .[Results]Compared with control group ,serum levels of LTE4 and TNF-αof observation group in spring and winter were increased significantly (LTE4:P 〈0 .05 in spring and P 〈0 .01 in winter)(TNF-α:all P 〈0 .01 in spring and winter) .There was no significant difference in serum levels of LTE4 and TNF-αin summer and autumn between two groups ( P〉0 .05) .Serum LTE4 had no obvious correlation with TNF-α.[Conclusion] Serum levels of LTE4 and TNF-α play an important role in the pathogenesis of SAR through local inflammatory response .They are of great reference value in clinical prevention and treatment . |
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Keywords: | Rhinitis,Allergic,Seasonal/BL Leukotriene E4/BL Tumor Necrosis Factor-alpha/BL |
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