H—rev107、TIG3、PSA在前列腺癌患者精浆及血清中的表达及其相关性 |
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引用本文: | 何毅平,舒友元,谢获,谢春意.H—rev107、TIG3、PSA在前列腺癌患者精浆及血清中的表达及其相关性[J].湖南医学,2014(1):70-72. |
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作者姓名: | 何毅平 舒友元 谢获 谢春意 |
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作者单位: | 广东省深圳市龙岗区南湾人民医院外科,广东深圳518000 |
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摘 要: | 目的]探讨前列腺癌患者精浆和血清中抑癌因子H-rev107和TIG3的表达水平及其与前列腺特异性抗原(PSA)的相关性。方法]ELISA法检测前列腺癌患者(试验组)和健康男性(对照组)血清及精浆中H-rev107、TIG3及PSA的表达水平。结果]试验组血清中H-rev107、TIG3及PSA表达均高于对照组(均P〈0.05),H-revl07和TIG3分别与PSA在血清中的水平呈正相关。精浆中H-rev107的表达试验组高于对照组(P〈0.05),但其TIG3和PSA表达两组间比较无统计学意义(P〉0.05)。结论]抑癌因子H-rev107和TIG3均表达于前列腺癌的血清及精浆中,H-rev107在血清及精浆均有较高的表达,H-rev107和TIG3分别与PSA在血清中的水平呈正相关。
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关 键 词: | 前列腺肿瘤 A液 前列腺特异抗原 血液 精液 |
Expression of H-rev107, TIG3 and PSA in Seminal Plasma and Serum of Patients with Prostate Carcinoma and Their Correlation |
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Institution: | HE Yi-ping , SHU You-yuan , XIE Huo , etal ( Department of Surgery, Nanwan People's Hospital of Longgang District, Shenzhen 518000, China ) |
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Abstract: | Objective] To explore the expressions of tumor suppressors H-rev107 and TIG3 in seminal plasma and serum Of patients with prostate carcinoma and their correlation with prostate-specific antigen(PSA). Methods] ELISA was used to detect the expression levels of H-rev107, TIG3 and PSA in serum and seminal plasma of patients with pros- tate carcinoma(experimental group) and healthy men(control group). Results] The expression levels of serum H- rev107, TIG3 and PSA in experimental group were higher than those in control group(all P 〈0.05). Serum levels of H- rev107 and TIG3 were positively correlated with PSA, respectively. The expression of H-rev107 in seminal plasma of ex- perimental group was higher than that in control group( P 〈0.05), but there was no significant different in the expres- sion of TIG3 and PSA between two groups( P 〉0. 05). Conclusion] Tumor suppressors H-rev107 and TIG3 are ex- pressed in serum and seminal plasma of prostate cancer. H-rev107 and TIG3 in serum are positively correlated with PSA, respectively. |
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Keywords: | Prostatic Neoplasms/BL Prostate-Specific Antigen/BL Semen |
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