白细胞介素-24及血管内皮生长因子-C 在宫颈鳞癌中的表达及临床意义

【目的】探讨白细胞介素-24（IL-24）及血管内皮生长因子C（VEGF-C）在宫颈浸润鳞癌组织中的表达及意义。【方法】采用免疫组织化学技术检测在正常宫颈组织（A组）、宫颈上皮内瘤样病变（B组）、宫颈浸润鳞癌组织（C组）中IL-24及VEGF-C的表达，分析其意义。【结果】A组IL-24高表达率显著高于B、C组，且B组显著高于C组；A组VEGF-C高表达率显著低于B、C组，且B组显著低于C组，其差异均有统计学意义（ P＜0．05）。宫颈鳞癌中IL-24的表达随着临床分期进展而降低，而与年龄，病理分级及间质浸润深度无关（ P ＞0．05）；宫颈癌淋巴结无转移组IL-24表达显著高于有淋巴结转移组（ P ＜0．05）；宫颈鳞癌中V EG F-C在不同临床分期及病理分级中表达无明显差异（ P ＞0．05），但淋巴结转移组的VEGF-C表达显著高于无淋巴结转移组（ P ＜0．05）。宫颈浸润鳞癌组IL-24与VEGF-C阳性表达率呈负相关（ P ＜0．05）。【结论】IL-24在正常宫颈组织，CIN及宫颈鳞癌中的阳性表达逐级降低且宫颈鳞癌淋巴有转移组几乎为阴性，而V EG F-C在其中的表达逐级增强且宫颈鳞癌淋巴有转移组高表达，两者呈明显的负相关，推断IL-24与VEGF-C可能与宫颈鳞癌的进展及淋巴转移有关。

Expression of IL-24 and VEGF-C in Cervical Squamous Carcinoma and Its Clinical Significance

Objective]To explore the expression of interleukin-24（IL-24） and vascular endothelial growth fac-tor-C（VEGF-C） in invasive cervical squamous carcinoma（CSC） and its significance .Methods]Immunohistochemi-cal method was used to detect the expression of IL-24 and VEGF-C in normal cervix（group A） ,cervical intraepi-thelial neoplasia（CIN ,group B） and invasive cervical squamous carcinoma（group C） .The significance was ana-lyzed .Results] The expression rate of IL-24 in group A was markedly higher than that in group B and group C , and that in group B was also markedly higher than that in group C .The expression rate of VEGF-C in group A was markedly lower than that in group B and group C ,and that in group B was markedly lower than that in group B ,and there was significant difference（ P〈0 .05） .The expression of IL-24 in CSC was decreased with the devel-opment of clinical stage ,but was not correlated with age ,pathological stage and interstitial invasion depth （ P〉0 . 05） .The expression of IL-24 in cervical cancer group without lymph node metastasis was markedly higher than that in cervical cancer group with lymph node metastasis （ P 〈0 .05） .There was no significant difference in the expression of VEGF-C in different clinical stage and pathological grade of CSC （ P 〉0 .05） ,but the expression of VEGF-C in lymph node metastasis group was markedly higher than that in no lymph node metastasis group （ P〈0 .05） .The expression of IL-24 in invasive CSC group was negatively related with VEGF-C（ P〈0 .05） .Conclu-sion]The expression of IL-24 in normal cervix tissue ,CIN and CSC is gradually decreased ,and it is negative in CSC group with lymph node metastasis .The expression of VEGF-C in CSC is increased gradually and higher in CSC group with lymph node metastasis .There is obviously negative correlation between IL-24 and VEGF-C .It suggests that IL-24 and VEGF-C may be associated with the development and lymph node metastasis of CSC .