Meta‐analysis: polymorphisms in TNF‐α gene promoter and Crohn’s disease |
| |
| Authors: | Z. Han C. Li S. Han Y. Han J. Qiu Y. Shi J. Wang A. Sun J. Ding K. Wu D. Fan |
| |
| Affiliation: | 1. Xijing Hospital of Digestive Diseases, State Key Library of Cancer Biology, Fourth Military Medical University, Xi’an, China.;2. Zheyi Han and Chunying Li contribute equally to this work.;3. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China. |
| |
| Abstract: | Aliment Pharmacol Ther 2010; 32: 159–170 Summary Background Tumour necrosis factor alpha (TNF‐α) is involved in the pathogenesis of Crohn’s disease (CD). However, results on the association between the polymorphisms in TNF‐α promoter and the risk of CD are inconsistent. Aim To perform a quantitative synthesis for the genetic polymorphisms in TNF‐α promoter and CD risk. Methods Databases were searched (up to 2009) and 31 studies were included. Risks of CD associated with the polymorphisms in TNF‐α promoter were assessed. Results Overall, individuals with ‐1031 TC+CC genotype had a slightly increased risk to develop CD compared with individuals with ‐1031 TT genotype (OR, 1.32; 95% CI, 1.03–1.70). In the further stratified analysis, we found Asians with the ‐1031T>C, ‐863 C>A and ‐857 C>T variant polymorphisms have almost one and a half CD risk compared with other genotypes (OR, 1.58; 95% CI, 1.16–2.15; OR, 1.55; 95% CI, 1.18–2.02; OR, 1.54; 95% CI, 1.19–1.99 respectively). We did not find ‐308 G>A variant associated with CD location and disease behaviours in stratified analysis. Conclusions TNF‐α polymorphisms in the promoter region might be used as a biomarker for CD risk prediction. Larger studies with mixed ethnicity subjects and stratified by clinical and sub clinical characteristics are needed to validate our findings. |
| |
| Keywords: | |
|
|
