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Effect of warming moxibustion Tianshu (ST 25, bilateral) and Qihai (CV 6) for the treatment of diarrhea-dominant irritable bowel syndrome: a patient-blinded pilot trial with orthogonal design
Authors:Yang Ling  Lu Yuan  Zhang Haifeng  Ma Xiaopeng  Bao Chunhui  Wu Huangan  Zhao Chen  Ding Guanghong  Qi Li  Zhou Shuang
Institution:1. Department of Mechanics and Engineering Science, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Fudan University, Shanghai 200433, China;2. Key Laboratory of Acupuncture-Moxibustion and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai Research Institute of Acupuncture and Meridians, Shanghai 200030, China;3. E-Institute of Shanghai Municipal Education Committee, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;4. Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Abstract:

Objective

To investigate the effects of warming moxibustion Tianshu (ST 25, bilateral) and Qihai (CV 6) in patients with diarrhea-dominant irritable bowel syndrome (D-IBS) by assessing predominant factors, and determining the best factor combinations and their interactions. To identify the optimal quantity of warming moxibustion Tianshu (ST 25, bilateral) and Qihai (CV 6) to achieve optimal efficacy.

Methods

An L9 (34) orthogonal design was applied to 233 confirmed subjects based on the three most influential factors and the three most frequently used levels. Nine programs were designed. Subjects were assigned to four subgroups according to age and gender; each subject underwent one of the nine programs randomly. We selected Tianshu (ST 25, bilateral) and Qihai (CV 6). The scores of symptoms and the IBS Quality of Life (IBS-QOL) were evaluated after the final treatment.

Results

After treatment, clinical symptoms of all patients were significantly improved (P = 0.001). Quality of life also improved significantly (P < 0.05). For all the participants, frequency was the dominating factor regarding symptoms (P = 0.01). Duration was the dominating factor for quality of life (P = 0.0001). The best combination for improving symptoms in 30–40-year-old male and female patients was two courses of 10 min each once a day, and for 41–50-year-old male and female patients it was three courses of 10 min (males) or 30 min (females) twice a day. The best combination for quality of life was three courses of 20 min once a day. No interaction was found between frequency and course, or frequency and duration.

Conclusion

Warming moxibustion Tianshu (ST 25, bilateral) and Qihai (CV 6) is a promising therapy for D-IBS. To acquire optimal efficacy, the three main factors (duration, frequency and treatment course) of the warming moxibustion should reach a specific quantity and be combined appropriately.
Keywords:Irritable bowel syndrome  Diarrhea  Warming moxibustion  Point ST25 (Tianshu)  Point CV6 (Qihai)  Quality of life
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