Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes |
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| Authors: | Hisako Matsumoto Yoshihiro Kanemitsu Tadao Nagasaki Yuji Tohda Takahiko Horiguchi Hideo Kita Kazunobu Kuwabara Keisuke Tomii Kojiro Otsuka Masaki Fujimura Noriyuki Ohkura Katsuyuki Tomita Akihito Yokoyama Hiroshi Ohnishi Yasutaka Nakano Tetsuya Oguma Soichiro Hozawa Yumi Izuhara Michiaki Mishima |
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| Affiliation: | 1. Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan;2. Kinki Hokuriku Airway Disease Conference, Osaka, Japan;3. Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kinki University, Osaka, Japan;4. Department of Respiratory Internal Medicine, Fujita Health University Second Educational Hospital, Aichi, Japan;5. Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Hyogo, Japan;7. Department of Hematology and Respiratory Medicine, Kochi University, Kochi, Japan;11. Division of Respiratory Medicine, Department of Internal Medicine, Shiga University of Medical Science, Shiga, Japan;12. Hiroshima Allergy and Respiratory Clinic, Hiroshima, Japan;8. Shino-Test Corporation, Kanagawa, Japan;9. Laboratory for Respiratory and Allergic Diseases, Core for Genomic Medicine, Center for Integrative Medical Sciences, Institute of Physical and Chemical Research, Yokohama, Kanagawa, Japan;71. Department of Health Promotion, National Institute of Public Health, Wako, Saitama, Japan;112. Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan;123. Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University School of Medical Sciences, Aichi, Japan |
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| Abstract: | BackgroundSensitization to Staphylococcus aureus enterotoxin (SE) is a known risk factor for asthma susceptibility and severity. However, how SE sensitization is involved in asthma, particularly nonatopic asthma and/or late-onset asthma, remains uncertain.ObjectiveTo clarify the involvement of SE sensitization in nonatopic and/or late-onset asthma and its association with a polymorphism of the cysteinyl leukotriene receptor 1 gene (CysLTR1), which was examined because CysLT signaling is closely associated with late-onset eosinophilic asthma.MethodsWe assessed associations between sensitization to SE (A and/or B) and clinical indexes in 224 patients with asthma (mean age, 62.3 years; 171 women) from a cohort of the Kinki Hokuriku Airway Disease Conference, particularly those with nonatopic asthma (not sensitized to common aeroallergens) and/or late-onset asthma. Associations between SE sensitization and CysLTR1 polymorphism (rs2806489), a potential regulatory variant for atopic predisposition in women, were also assessed in a sex-stratified manner.ResultsA total of 105 patients (47%) with asthma were sensitized to SE. Among patients with nonatopic asthma (n = 67) or with late-onset asthma (n = 124), those sensitized to SE had significantly higher serum total IgE and periostin levels than those not sensitized. In nonatopic patients, a rapid decrease in forced expiratory volume in 1 second was associated with SE sensitization. In women with asthma, rs2806489 was associated with sensitization to SEB and age at asthma onset.ConclusionSE sensitization contributes to TH2 inflammation in nonatopic and/or late-onset asthma. In women with asthma, the CysLTR1 variant might be associated with sensitization to SEB and age at asthma onset. |
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