Mechanism of antitumor effect of a novel bFGF binding peptide on human colon cancer cells |
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| Authors: | Cong Wang Shaoqiang Lin Yanfang Nie Xinglong Jia Jing Wang Jian Xiao Jianzhang Wu Xiaokun Li Xiaoping Wu |
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| Institution: | 1. Institute of Tissue Transplantation and Immunology;2. Medical College, Jinan University, Guangzhou;3. These authors contributed equally to the work.;4. School of Pharmaceutical Science, Wenzhou Medical College, Wenzhou;5. College of Natural Resources and Environment, South China Agricultural University, Guangzhou, China |
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| Abstract: | Colon cancer is a leading cause of morbidity and mortality in Western countries. Basic fibroblast growth factor (bFGF) was up‐regulated in patients with colon cancer and was considered as a potential therapeutic target. In this study, we first demonstrated that a novel bFGF‐binding peptide (named P7) inhibited proliferation of several colon cancer cell lines including HT‐29, LoVo, and Caco2 cells stimulated by bFGF. Further investigations with HT‐29 cells indicated that P7 arrested the cell cycle at the G0/G1 phase of bFGF‐stimulated cells, reduced the levels of phospho‐Erk1/Erk2 induced by bFGF, and caused significant changes in the expression of proteins related to proliferation, cell cycle, and cancer. Our results suggested that the bFGF‐binding peptide has a potential antitumor effect on colon cancer. (Cancer Sci 2010; 101: 1212–1218) |
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