Antiarrhythmic effects and ionic mechanisms of oxymatrine from Sophora flavescens |
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| Authors: | Cao Yong‐gang Jing Shan Li Lei Gao Jing‐quan Shen Zhi‐ying Liu Yan Xing Yan Wu Ming‐li Wang Ye Xu Chang‐qing Sun Hong‐li |
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| Institution: | 1. Department of Pharmacology, Daqing Campus of Harbin Medical University, Daqing, 163319, P. R. China;2. Cao Yong‐gang and Jing Shan made equal contribution to this study.;3. Department of Cardiology, Peking University People's Hospital, Beijing, 100044, P. R. China;4. Department of Surgery, Fifth Clinical College of Harbin Medical University, Daqing, 163316, P. R. China;5. Department of Clinical Nursing, Daqing Campus of Harbin Medical University, Daqing, 163319, P. R. China;6. Department of Pharmaceutical Botany, Daqing Campus of Harbin Medical University, Daqing, 163319, P. R. China;7. Department of Pharmacology, Harbin Medical University, Harbin, 150081, P. R. China;8. Department of Pathophysiology, Harbin Medical University, Harbin, 150081, P. R. China |
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| Abstract: | Accumulating evidence indicates that oxymatrine may exert protective effects on the cardiovascular system. This study was designed to evaluate the antiarrhythmic effects as well as the electrophysiological properties of oxymatrine. The antiarrhythmic activity of oxymatrine was observed in a rat model of arrhythmia induced by coronary ligation. Action potential duration (APD), L‐type calcium current (ICa‐L), transient outward potassium current (Ito) and inward rectifier potassium current (IK1) in rat ventricular myocytes were recorded by utilizing the whole cell patch‐clamp technique. The results showed that administration of oxymatrine significantly delayed the onset of ventricular arrhythmia, decreased the duration of ventricular arrhythmia and reduced the arrhythmia score of arrhythmic rats. The beneficial effects of oxymatrine may be related to the shortening of APD through reduction of ICa‐L, enhancement of Ito and inhibition of IK1. Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | oxymatrine arrhythmia APD ion channel |
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