Translational Mini‐Review Series on Th17 Cells: CD4+ T helper cells: functional plasticity and differential sensitivity to regulatory T cell‐mediated regulation |
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| Authors: | R A O'Connor L S Taams S M Anderton |
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| Institution: | 1. University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen's Medical Research Institute,;2. Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, and;3. Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection and Inflammatory Disease, King's College London, London, UK |
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| Abstract: | Atherosclerosis is a chronic inflammatory disease. Immunomodulation of atherosclerosis emerges as a promising approach to prevention and treatment of this widely prevalent disease. The function of high‐density lipoprotein (HDL) to promote reverse cholesterol transport may explain the ability of its protection against atherosclerosis. Findings that HDL and apolipoprotein A‐I (apoA‐I) inhibited the ability of antigen presenting cells (APCs) to stimulate T cells might be attributed to lipid raft, a cholesterol‐rich microdomain exhibiting functional properties depending largely upon its lipid composition. Thus, modulating cholesterol in lipid raft may provide a promising anti‐atherogenic strategy. |
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| Keywords: | suppression Th1 Th2 Th17 Treg |
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