| 拉米夫定联合疗肝3号对乙型肝炎病毒YMDD变异的影响及机制分析 |
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| 引用本文： | 涂燕云,张红星,陈枝俏,蒋阳昆,林海. 拉米夫定联合疗肝3号对乙型肝炎病毒YMDD变异的影响及机制分析[J]. 右江民族医学院学报, 2008, 30(5) |
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| 作者姓名： | 涂燕云 张红星 陈枝俏 蒋阳昆 林海 |
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| 作者单位： | 广西中医学院附属瑞康医院肝胆内科,广西,南宁,530011 |
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| 基金项目： | 广西中医学院院级重点课题 |
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| 摘 要： | 目的观察拉米夫定联合疗肝3号对乙型肝炎病毒YMDD变异的影响。方法将80例慢性乙型肝炎(CHB)患者随机分为治疗组和对照组,治疗组40例为联合应用拉米夫定和疗肝3号;对照组40例为单用拉米夫定,疗程均为18个月,每3个月分别检测肝功能、乙型肝炎病毒血清学标志物、HBV DNA、YMDD变异株、T淋巴细胞亚群。结果在治疗12个月时,治疗组出现2例(5.00%)变异,对照组5例(12.50%),差异无显著性(P>0.05);在治疗18个月时,治疗组出现4例(10.00%)变异,对照组12例(30.00%),差异有显著性(P<0.05)。停药6个月后治疗组在HBV-DNA阴转、HBeAg/抗-HBe血清转换、HBeAg阴转上明显优于对照组(P均<0.05)。治疗组外周血CD4+亚群水平上调,CD4+/CD8+比值趋于正常,停药6个月后仍持续保持高水平,与对照组比较差异有高度显著性(P均<0.01)。结论拉米夫定联合疗肝3号有调节CHB患者细胞免疫水平的作用,可减少YMDD变异的发生。
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| 关 键 词： | 肝炎,乙型,慢性 基因变异 拉米夫定 疗肝3号 |
Lamivudine in combination with Liaogansanhao in treatment of patients with chronic hepatitis B and its effects on YMDD variants |
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| TU Yan-yun,ZHANG Hong-xing,CHEN Zhi-qiao,JIANG Yang-kun,LIN Hai. Lamivudine in combination with Liaogansanhao in treatment of patients with chronic hepatitis B and its effects on YMDD variants[J]. Journal of Youjiang Medical College For Nationalities, 2008, 30(5) |
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| Authors: | TU Yan-yun ZHANG Hong-xing CHEN Zhi-qiao JIANG Yang-kun LIN Hai |
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| Affiliation: | TU Yan-yun,ZHANG Hong-xing,CHEN Zhi-qiao,JIANG Yang-kun,LIN Hai (Internal Hepatobiliary Department,Affiliated Ruikang Hospital to Guangxi TCM University,Nanning,Guangxi 530011,China) |
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| Abstract: | Objective To observe the effects of traditional Chinese medicine Liaogansanhao in combination with lamivudine in treatment of patients with chronic hepatitis B(CHB) and its effects on YMDD variants.Methods 80 patients were enrolled and randomized into two groups: the treated group of 40 cases,treated with Liaogansanhao in combination with lamivudine;the control group of 40 cases,treated with lamivudine alone.One cycle lasted for 18 months,every 3 months,the liver function,virological markers of HBV,serum HB... |
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| Keywords: | hepatitis B chronic gene variants lamivudine Liaogansanhao |
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