Intense hypoxic cycle exercise does not alter lung density in competitive male cyclists |
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Authors: | M J MacNutt J A Guenette J D Witt R Yuan J R Mayo D C McKenzie |
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Institution: | (1) School of Human Kinetics, University of British Columbia, Vancouver, Canada;(2) Department of Radiology, Vancouver General Hospital, Vancouver, Canada |
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Abstract: | We tested the hypothesis that intense short duration hypoxic exercise would result in an increase in extravascular lung water
(EVLW), as evidenced by an increase in lung density. Using computed tomography (CT), baseline lung density was obtained in
eight highly trained male cyclists (mean ± SD: age = 28 ± 8 years; height = 180 ± 9 cm; mass = 71.6 ± 8.2 kg;
= 65.0 ± 5.2 ml kg min−1). Subjects then completed an intense hypoxic exercise challenge on a cycle ergometer and metabolic data, HR and %SpO2 were recorded throughout. While breathing 15% O2, subjects performed five 3 km cycling intervals (mean power, 286 ± 20 W; HR = 91 ± 4% HRmax) separated by 5 min of recovery. From a resting hypoxic SpO2 of 92 ± 4%, subjects further desaturated during exercise to 76 ± 3%. CT scans were repeated 76 ± 10 min (range 63–88 min)
following the completion of exercise. There was no change in lung density from pre (0.18 ± 0.02 g ml−1) to post-exercise (0.18 ± 0.04 g ml−1). The substantial reduction in SpO2 may be explained by a number of potential mechanisms, including decreased pulmonary diffusion capacity, alveolar hypoventilation,
reduced red cell transit time, ventilation/perfusion inequality or a temperature and pH induced rightward-shift in the oxyhaemoglobin
dissociation curve. Alternatively, the integrity of the blood gas barrier may have been disrupted without any measurable increase
in lung density. |
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Keywords: | Cycle exercise Hypoxia Extravascular lung water Lung density Computed tomography |
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