| 10日序贯疗法与标准三联疗法治疗幽门螺杆菌感染的疗效分析 |
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| 引用本文： | 王荣欣,秦俭.10日序贯疗法与标准三联疗法治疗幽门螺杆菌感染的疗效分析[J].重庆医学,2009,38(18). |
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| 作者姓名： | 王荣欣 秦俭 |
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| 作者单位： | 首都医科大学宣武医院急诊科,北京,100053;首都医科大学宣武医院急诊科,北京,100053 |
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| 摘 要： | 目的 比较埃索美拉唑、阿莫西林、克拉霉素、替硝唑组成的10d序贯疗法与标准三联疗法根除幽门螺杆菌(HP)的疗效.方法 将本院经胃镜检查确诊为慢性胃炎和消化性溃疡且HP阳性的102例患者分为两组,治疗组(50例)方案:前5d埃索美拉唑20mg、阿莫西林1 000mg,每日2次;后5d埃索美拉唑20mg、克拉霉素500mg、替硝唑500mg,每日2次.对照组(52例)标准三联疗法:埃索美拉唑20mg、克拉霉素500mg、阿莫西林1 000mg,每日2次,疗程7d.结果 治疗组HP根除率为92.00%,对照组76.92%,两组比较差异具有统计学意义(P<0.05).两种方案不良方应的发生率差异无统计学意义(P>0.05).结论 以埃索美拉唑、阿莫西林、克拉霉素、替硝唑组成的10日序贯疗法治疗幽门螺杆菌感染明显优于7d标准三联疗法,是一种安全、有效的方案选择.
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| 关 键 词： | 序贯疗法 幽门螺杆菌感染 三联疗法 |
Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication |
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| WANG Rong-xin,QIN Jian.Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication[J].Chongqing Medical Journal,2009,38(18). |
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| Authors: | WANG Rong-xin QIN Jian |
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| Institution: | WANG Rong-xin,QIN Jian(Department of Emergency,Xuanwu Hospital,Capital Medical University,Beijing 100053,China) |
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| Abstract: | Objective To determine whether sequential therapy eradicates Helicobactor pylori(HP) infection better than standard triple-drug therapy for adults with chronic gastritis and peptic ulcer.Methods 102 patients with HP positive were randomly divided into two groups.50 patients received 10d sequential therapy esomeprazole(20mg twice daily) plus amoxicillin(1 000mg twice daily) for the first 5d,followed by esomeprazole(20mg),clarithromycin(500mg) and tinidazole(500mg) twice daily for the remaining 5d].52 patien... |
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| Keywords: | Helicobacter pylori infection sequential therapy triple therapy |
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