Activation of nuclear factor kappa B and induction of migration inhibitory factor in tumors by surgical stress of laparotomy versus carbon dioxide pneumoperitoneum: an animal experiment |
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| Authors: | Anwar Tawfik Amin Norio Shiraishi Shigeo Ninomiya Masaaki Tajima Masafumi Inomata Seigo Kitano |
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| Affiliation: | (1) Department of Gastroenterological Surgery, Oita University Faculty of Medicine, 1-1 Idaigaoka, Yufu, Oita 879-5593, Japan;(2) South Egypt Cancer Institute, Surgery Department, Assiut University, Assiut, Egypt |
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| Abstract: | Background Surgical trauma may be associated with enhanced tumor growth and establishment. The authors studied the effect of carbon dioxide (CO2) pneumoperitoneum versus laparotomy on tumor necrosis factor-α (TNFα), migration inhibitory factor (MIF) expression, and nuclear factor kappa B (NFκB) activity in human gastric cancer. |
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