| 贻贝多糖胶囊毒理学安全性研究 |
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| 引用本文： | 吴涓,孙倩,储智勇,祝德秋,汪家春,栾洁,张术. 贻贝多糖胶囊毒理学安全性研究[J]. 中国卫生检验杂志, 2011, 0(1): 97-100 |
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| 作者姓名： | 吴涓 孙倩 储智勇 祝德秋 汪家春 栾洁 张术 |
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| 作者单位： | 同济大学附属同济医院药剂科;海军医学研究所; |
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| 基金项目： | 上海鲲禹科贸有限公司资助 |
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| 摘 要： | 目的:对贻贝多糖胶囊的食用安全性进行毒理学评价。方法:采用急性毒性实验、遗传毒性实验(Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验)和30 d喂养试验进行评价。结果:小鼠经口MTD均大于15.0 g/kg,Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验三项遗传毒性试验结果均为阴性。30 d喂养试验未见大鼠的生长发育、血液学、生化、脏器比及组织病理学有异常变化。结论:贻贝多糖胶囊急性毒性分级属无毒级,无遗传毒性,最大无损害作用剂量大于1.6 g/kg,相当于人体推荐摄入量的120倍。在本实验剂量范围内,贻贝多糖胶囊属安全性保健食品。
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| 关 键 词： | 贻贝多糖胶囊 毒理学 安全性 |
A toxicological security study of Mytihus Edulis Linnaeus Polysaccharides Capsule |
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| WU Juan,SUN Qian,CHU ZHi-yong,ZHU De-qiu,WANG Jia-chun,LUAN Jie,ZHANG Shu. A toxicological security study of Mytihus Edulis Linnaeus Polysaccharides Capsule[J]. Chinses Journal of Health Laboratory Technology, 2011, 0(1): 97-100 |
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| Authors: | WU Juan SUN Qian CHU ZHi-yong ZHU De-qiu WANG Jia-chun LUAN Jie ZHANG Shu |
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| Affiliation: | WU Juan1,SUN Qian2,CHU ZHi-yong2,ZHU De-qiu1,WANG Jia-chun2,LUAN Jie2,ZHANG Shu2 (1.Dept.of Pharmaceutical Preparation Section,Tongji Hospital of Tongji University,Shanghai 200065,China,2.Naval Medical Research Institute,Shanghai 200433,China) |
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| Abstract: | Objective:To estimate the toxicological characterization of mytihus edulis linnaeus polysaccharides(MELP) capsule.Motheds: Acute toxicity test,genetic toxicity test(Ames test,micronucleus test of born marrow in mice,sperm shape abnormality test in mice) and thirty-day feeding test in rats were used in this study according to the procedures for toxicological assessment of food.Results: The oral MTD in mice was more than 15.0 g/kg,the results of Ames test,micronucleus test of born marrow in mice and sperm sha... |
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| Keywords: | Mytihus edulis Linnaeus polysaccharides capsule Toxicology Security |
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