| Notch-1在甲状腺乳头状癌中的表达及意义 |
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| 引用本文： | 金晓燕,梁勇,陈佳玉,姚军,杨林军,周健,王旭林. Notch-1在甲状腺乳头状癌中的表达及意义[J]. 中国卫生检验杂志, 2011, 0(1): 1-3 |
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| 作者姓名： | 金晓燕 梁勇 陈佳玉 姚军 杨林军 周健 王旭林 |
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| 作者单位： | 温州医学院第一临床学院肿瘤科;台州学院医学院附属台州市立医院肿瘤科;台州学院医学院检验系; |
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| 基金项目： | 国家“十一五”863“生物医学关键试剂”重点项目(2006AA02090406B) |
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| 摘 要： | 目的:探讨Notch-1在甲状腺乳头状癌中的表达特点及其生物学意义.方法:应用免疫荧光法和RT-PCR 法,分别检测人甲状腺乳头状癌组织标本中,Notch-1基因和蛋白的表达情况.结果:RT-PCR检测,甲状腺乳头状癌组织中Notch-lmRNA的表达明显低于正常甲状腺组织;免疫荧光法测定,Notch-1在正常甲状腺组...
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| 关 键 词： | 甲状腺乳头状癌 Notch-1 信号传导 |
Patterns of notch-1 expression in papillary thyroid cancer and their oncological significance |
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| JIN Xiao-yan,LIANG Yong,CHEN Yu-Jia,YAO Jun,YANG Lin-jun,ZHOU Jian,WANG Xu-lin. Patterns of notch-1 expression in papillary thyroid cancer and their oncological significance[J]. Chinses Journal of Health Laboratory Technology, 2011, 0(1): 1-3 |
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| Authors: | JIN Xiao-yan LIANG Yong CHEN Yu-Jia YAO Jun YANG Lin-jun ZHOU Jian WANG Xu-lin |
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| Affiliation: | JIN Xiao-yan1,LIANG Yong2,CHEN Yu-Jia3,YAO Jun3,YANG Lin-jun2,ZHOU Jian2,WANG Xu-lin2(1.Oncology,The First Affiliated Hospital of WenZhou Medical College,Wenzhou 325000,China,2.Department of oncology,Zhejian Taizhou Municipal Hospital,Taizhou 318000,3.Laboratory Department of Taizhou Univetsity Medical College,China) |
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| Abstract: | Objective:To study the Notch-1 mRNA and its protein expression in papillary thyroid cancer and analyze its clinical biological significance.Methods:Using RT-PCR technology and immunofluorescence in exactly the same experimental conditions,were used to detect human thyroid papillary carcinoma tissues,compare with normal thyroid tissues.Results: RT-PCR in thyroid papillary cancer tissues,the expression of Notch-1 mRNA were significantly weaker than normal thyroid tissue(P<0.05);In immunofluorescence,Notch-1 i... |
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| Keywords: | Papillary thyroid cancer Notch-1 Signaling pathway |
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