CTLA-4 +49A>G polymorphism is associated with the risk but not with the progression of colorectal cancer in Chinese期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

CTLA-4 +49A>G polymorphism is associated with the risk but not with the progression of colorectal cancer in Chinese

Authors:	Peng Qi Can-ping Ruan Hao Wang Fei-guo Zhou Xin-yun Xu Xing Gu Yun-peng Zhao Tong-hai Dou Chun-fang Gao

Affiliation:	(1) Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, 200438, China;(2) Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China;(3) Department of Laboratory Medicine, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China;(4) Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, 200438, China;(5) Institute of Genetics, Fudan University, Shanghai, 20043, China;

Abstract:	Purpose Colorectal cancer (CRC) is one of the most common malignancies in the world and a multipathway disease. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a potent immunoregulatory molecule that suppresses antitumor response by down-regulating T-cell activation. The most studied +49A>G polymorphism of CTLA-4 gene has been associated with several autoimmune or cancer diseases. Our aim was to investigate the association between this genetic variant and the risk as well as progression of colorectal cancer in Chinese.

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