加味当归四逆汤联合甲钴胺和胰岛素强化疗法治疗糖尿病周围神经病变的临床效果观察

目的：探究联合甲钴胺和胰岛素强化疗法并应用加味当归四逆汤治疗糖尿病周围神经病变的临床疗效。方法：将2011年5月～2012年8月就诊的210例糖尿病周围神经病变患者随机分为对照组和治疗组，对照组仅应用甲钴胺静脉滴注和胰岛素强化疗法，治疗组在应用甲钴胺静脉滴注和胰岛素强化疗法的基础上加服当归四逆汤。两组患者各连续治疗1个月，观察综合的临床疗效，并用多伦多临床临床评分系统对两组患者治疗前后进行评分判断治疗效果。结果：两组治疗前后在临床治疗效果和多伦多临床评分上均有显著性差异，并且治疗组的治疗效果优于对照组，P〈O．05，具有统计学意义。结论：联合甲钴胺和胰岛素强化疗法并应用加味当归四逆汤治疗糖尿病周围神经病变的疗效显著。

Clinical observation on treating DPN with integrated application of mecobalamine and insulin strengthen therapy combined with modified Danggui Sini decoction

Objective： To investigate the clinical effect of integrated application of mecobalamine and insulin strengthen therapy combined with modified Danggui Sini decoction on treating diabetic peripheral neuropathy. Methods： 210 patients collected from May 2011 to August 2012 were randomly divided into the control group and the treatment group. The control group was only given mecobalamine i.v. and insulin strengthen treatment, while the treatment group was given modified Danggui Sini decoction more. Both groups were treated for a month to observe the clinical efficacy, and Toronto clinical scoring system was applied to assess the treatment effect in both groups. Results： Significant differences were detected both in the clinical effects before and after treatment and in the Toronto clinical scores. And the therapeutic efficacy in the treatment group was significantly better （P〈0.05）. Conclusion： The integrated application of mecobalamine and insulin strengthen therapy combined with modified Danggui Sini decoction was effective in treating diabetic peripheral neuropathy.