罗格列酮联合阿托伐他汀治疗对血脂正常的2型糖尿病患者颈动脉硬化的影Ⅱ向

目的 观察罗格列酮联合阿托伐他汀治疗对血脂正常的2型糖尿病患者颈动脉硬化（CAS）的影响.方法 将218例血脂正常的2型糖尿病患者随机分为对照组、罗格列酮组、阿托伐他汀组和罗格列酮阿托伐他汀联合组.治疗前后分别检查颈动脉内中膜厚度（IMT）、管腔内径、斑块的数量和类型.结果 治疗6个月后罗格列酮和阿托伐他汀均可使2型糖尿病患者颈动脉IMT变薄、管腔内径增大、斑块的数量减少和斑块类型改变（P〈0.05）.罗格列酮阿托伐他汀联合治疗上述指标的改变更明显,对颈动脉硬化的影响效果优于单用罗格列酮或阿托伐他汀（P〈0.05）.结论 使用罗格列酮和阿托伐他汀均可延缓血脂正常的2型糖尿病患者CAS斑块的发生,同时可在一定程度上发挥稳定斑块的作用,两者合用对CAS进展的影响更大.

The effect of Rosiglitazone and Atorvastatin on carotid atherosclerosis in type 2 diabetes mellitus patients with normal cholesterol

Objective To observe the effect of Rosiglitazone and Atorvastatin on carotid atherosclerosis in type 2 diabetes mellitus （T2DM）patients with normal cholesterol. Methods 218 cases of T2DM patients were randomly divided into four groups：conventional therapy group, Rosiglitazone group, Atorvastatin group and the combination of Rosiglitazone and Atorvastatin. The numbers and types of their carotid atheromatous plaques,carotid inner diameters, carotid intima-media thickness（IMT） were measured with Doppler uhrasonography before and after six months＇ treatment. Results The plagues,numbers and IMT decreased,the plagucs,type changed by the treatment with Rosiglitazone or Atorvastatin respectively （P 〈 0.05 ）and were markedly changed in the group treated by the combination of Rosiglitazone and Atorvastatin（ P 〈 0.01 ）for six months＇ treatmennt. The Conlbination of Rosiglitazone and Atorvastatin had better effects on changing carotid atherosclerosis than Rosiglitazone or Atorvastatin alone. Conclusion To some extent, Rosiglitazone or Atorvastatin alone all can retard atherosclerosis progression and stable arterial plague in T2DM patients with normal cholesterol,but their combination had better effects.