The effect of modafinil on self-esteem in spinal cord injury patients: a report of 2 cases and review of the literature |
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Authors: | Mukai Ai Costa Jonathan L |
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Affiliation: | Department of Physical Medicine and Rehabilitation, Northwestern University, McGraw Medical Center, and Rehabilitation Institute of Chicago, Chicago, IL 60611, USA. aimukai355@yahoo.com |
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Abstract: | We report on 2 cases of the effect of modafinil on the self-esteem of patients with spinal cord injury (SCI). The first patient was a 33-year-old man with history of polysubstance abuse and a C6 American Spinal Injury Association (ASIA) grade A injury, who presented for follow-up to the outpatient rehabilitation clinic for depression, decreased motivation, and lowered self-esteem. The patient had tried a selective serotonin reuptake inhibitor (SSRI) without success, and reported increasing social and legal stressors. Within 1 month of starting on modafinil, he reported increased self-esteem and motivation, as well as decreased self-consciousness. The second patient was a 36-year-old woman with history of depression and a T11 ASIA grade A injury. She tried various SSRIs for depression and adjustment issues before she was started on modafinil. She lost weight and became more assertive and less self-conscious within 1 month after starting on modafinil. These 2 cases suggest that modafinil should be studied as a therapeutic option for treating lowered self-esteem in patients with SCI. |
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Keywords: | Benzhydryl compounds Case report Rehabilitation Self concept Spinal cord injuries |
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