在缺钾条件下氯化钡引起心肌坏死的机制的实验研究

<正> 人们早就知道钡是一种肌肉毒,对骨骼肌、平滑肌和心肌都有刺激作用,可使冠状动脉收缩造成心肌缺血缺氧。但对于钡能引起心肌坏死的问题却很少有人注意,这方面的资料极少。1963年王凡等首先发现,慢性钡中毒可使大鼠发生灶状心肌坏死。后来又看到,在缺钾条件下钡引起的心肌坏死大大加速和加重。

EXPERIMENTAL STUDIES ON THE PATHOGENESIS OF BARIUM-INDUCED MYOCARDIAL NECROSIS IN CONDITIONS OF POTASSIUM DEFICIENCY

The pathogenesis of barium-induced severe myocardial necrosis in dietary potassum-depleted rats was investigated. In this study four experiments were performed. The results of these experiments suggest that there exist a complex pathogenesis of myocardial lesion produced by barium in condition of potassium deficiency. The main mechanism seems to be the direct stimulating effect of barium on myocardial contractibility. It seems unlikely that barium-induced constriction of coronary arteries, hypertension, hypokalemia, and increased catecholamine secretion are the basic mechanism of the myocardial necrosis. But these factors may play a promoting or aggravating role in the development of the myocardial lesion. Potassium deficiency not only acts as a conditioning factor for barium-induced myocardial necrosis, but also relatively increases the cardiotoxity of barium. This may be the principal pathogenesis of severe myocardial necrosis produced by barium in combination with potassium deficiency.