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| 吗丙嗪和雷佐生抑制兔红细胞膜钙调蛋白活力的比较 | |
| 引用本文： | 卢大用,沈祖铭,陈恩鸿,周建军,胥彬,堀江清史,曹静懿.吗丙嗪和雷佐生抑制兔红细胞膜钙调蛋白活力的比较[J].中国药理学与毒理学杂志,2001,15(1):76-78. |
| 作者姓名： | 卢大用 沈祖铭 陈恩鸿 周建军 胥彬 堀江清史 曹静懿 |
| 作者单位： | 1. 上海大学生命科学学院, 上海 200436 2. 中国科学院上海药物研究所, 上海 200031 3. 日本旭化成工业株式会社, 东京 101-8481 |
| 基金项目： | 上海市高等教育科技发展基金 |
| 摘 要： | 比较了抗癌结构类似物吗丙嗪和雷佐生对红细胞膜钙调蛋白 (CaM)活性的影响 .观察兔红细胞膜Ca2 +,Mg2 + ATP酶 (CaM的靶酶 )活性反映膜CaM激活ATP酶的活性 .结果显示吗丙嗪 ( 0 .1～ 1mmol·L- 1)浓度依赖性抑制CaM激活ATP酶活性 (下降11%～ 32 % ) .雷佐生在高浓度 ( 0 .5mmol·L- 1)仍未显示抑制CaM激活ATP酶活性的作用 .吗丙嗪在低浓度 ( 0 .0 2～ 0 .1mmol·L- 1)能增加N 乙酰神经氨酸( 0 .2mmol·L- 1)抑制CaM激活ATP酶活性的作用 .结果表明吗丙嗪对CaM活性的抑制作用强于雷佐生 ,因而可能在CaM介导的抑瘤途径的作用较雷佐生强 ,且其作用可能与神经氨酸 (唾液酸 )有关 |
| 关 键 词： | 钙调蛋白 吗丙嗪 雷佐生 抗肿瘤药物 唾液酸 |
| 收稿时间： | 2000-4-7 |
Comparison between probimane and razoxane on inhibiting calmodulin activity of rabbit erythrocyte membrane |
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| LU Da-Yong, CHEN En-Hong, CAO Jing-Yi, ZHOU Jian-Jun, SHEN Zu-Ming, XU Bin, HORIE Kiyoshi.Comparison between probimane and razoxane on inhibiting calmodulin activity of rabbit erythrocyte membrane[J].Chinese Journal of Pharmacology and Toxicology,2001,15(1):76-78. | |
| Authors: | LU Da-Yong CHEN En-Hong CAO Jing-Yi ZHOU Jian-Jun SHEN Zu-Ming XU Bin HORIE Kiyoshi |
| Institution: | (1. School of Life Science, Shanghai University, Shanghai 200436, China; 2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China; 3. Asashi Chemical Industry Co Ltd, Tokyo 101-8481, Japan) |
| Abstract: | To compare the effects of antitumor derivatives probimane andrazoxane on calmodulin(CaM) in rabbit erythrocytes by observing CaM activated Ca2+,Mg2+-ATPase activity of rabbit erythrocyte membranes. It was showed that probimane (0.1－1.0 mmol.L-1) inhibited cell CaM activated Ca2+,Mg2+-ATPase activity (decreasing 11%－32%) in a dose-dependent manner. Razoxane at a concentration of 0.5 mmol.L-1 did not inhibit CaM activated Ca2+,Mg2+-ATPase activity. Probimane at low concentrations (0.02－0.1 mmol.L-1) enhanced the inhibitory effect of N-acetylneuraminic acid on CaM activated Ca2+,Mg2+-ATPase activity. The results manifest that probimane may be more potent to CaM pathways of tumor than razoxane does and its effect might be correlated with neuraminic acids(sialic acids). |
| Keywords: | calmodulin probimane razoxane antineoplastic agents sialic acids |
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