乙醇对犬消化间期及餐后胃和十二指肠收缩的影响

为了探讨饮酒引起消化不良的机理 ,本文应用低顺应性毛细管水灌注消化道腔内测压系统记录清醒犬胃和十二指肠收缩活动并在犬消化间期胃肠移行性复合运动 (MMC)不同时相抽取静脉血 ,观察胃内灌流乙醇对MMC和餐后胃肠运动的作用及血浆胃动素浓度变化 .结果表明 :①在MMCⅡ相后期从胃管内灌流 15 %乙醇延长了MMC周期时间 ,灌流乙醇后出现的MMCⅢ相收缩时间 ,振幅和动力指数明显低于正常对照灌流 30 %乙醇则抑制了MMCⅢ相出现 .②血浆胃动素随MMC不同时相呈周期性波动 ,血浆胃动素浓度在MMCⅢ相时最高 ,MMCⅠ相时最低 .在灌流 15 %乙醇后出现MMCⅢ相时 ,血浆胃动素高峰浓度降低 .灌流 30 %乙醇则抑制了消化间期血浆胃动素浓度高峰出现 .③在犬进餐后灌流 30 %乙醇明显抑制了餐后胃和十二指肠的收缩活动 .因此 ,胃内灌流乙醇减弱了犬消化间期和餐后胃和十二指肠的收缩 ,血浆胃动素释放减少可能部分介导了乙醇的胃肠抑制作用 .结果提示这可能是饮酒引起临床消化不良的原因 .

Effect of ethanol on interdigestive and postprandial contractile activities in gastric antrum and duodenum of dogs

To explore the mechanism in which alcohol induces dyspepsia, the study was designed to record the contractile activities in the gastric antrum and duodenum in conscious dogs, by using low compliance capillary water perfusion manometric system. Blood samples in various phases of migrating motor complex(MMC) were drawn for measuring plasma motilin concentrations. The effect of intragastric infusion of ethanol on interdigestive MMC and postprandial gastrointestinal contractions, and the change in plasma motilin were observed. The results showed: ①The duration , amplitude and motility index of phase occurred after intragastric perfusion of 15% ethanol at later phaseⅡ significantly decreased as compared with control group(P<0.05 ). Intragastric infusion of 30% ethanol blocked the occurrence of MMC phase. ②Plasma motilin level showed cyclical fluctuations in different phases of MMC, it reached a peak during phaseⅢ and was the lowest during phaseⅠ in control group. The peak of plasma motilin level was lower in phaseⅢ after infusion of 15% ethanol than that of spontaneous phaseⅢ(P<0.05), and absent after infusion of 30% ethanol. ③Intragastric infusion of 30% ethanol obviously attenuated postprandial gastrointestinal contractile activity (P<0.01). So it is concluded that ethanol inhibits MMC and postprandial contractions in canine gastric antrum and duodenum, and that decreasing release of plasma motilin may be partially involved in its actions, suggesting it account for the alcohol-induced indigestion in man.