Effects of eight-week treatment with histamine H2-antagonists or an antacid on plasma levels of histamine and serotonin in duodenal ulcer patients |
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| Authors: | K H Lai C H Cho C W Ogle J Y Wang |
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| Affiliation: | 2. Division of Gastroenterology, Department of Internal Medicine, Veterans General Hospital, Taipei, Taiwan;1. Department of Pharmacology, Faculty of Medicine, University of Hong Kong, Hong Kong, Japan;1. Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX;2. Department of Medicine, Baylor College of Medicine, Houston, TX;3. Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey Veterans Affairs Medical Center, Health Services Research and Development Center of Innovation, Houston, TX;4. Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX;1. Department of Nursing, Baika Women’s University, 2-19-5 Shukunosho, Ibaraki, Osaka 567-8578, Japan;2. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita-shi, Osaka 565-0871, Japan;3. Osaka Medical Center for Cancer and Cardiovascular Disease Prevention, 1-3-3 Nakamichi, Higashinari-ku, Osaka, 537-8511, Japan;1. College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou, 350002, China;2. Guangxi State-owned Sanmenjiang Forest Farm, Guiliu Road, Chengzhong District, Liuzhou 545006, China;3. College of Environmental and Biological Engineering, Putian University, Putian, 351100, China;1. Centre d’Etudes Paléopathologiques du Nord, 36 rue Jules Ferry, 59127 Walincourt-Selvigny, France;2. University of Caen, CNRS-CRAHAM-UMR 6273, Esplanade de la Paix, CS, 14032 Caen Cedex, France;3. University Paris-Est Créteil-Val de Marne, Faculté de Médecine, LIC-EA 4393, 51 avenue du Maréchal Delattre de Tassigny, 94010 Créteil Cedex, France;4. Lille University, Forensic Taphonomy Unit – Anthropology, Lille Forensic Institute, 59000, France;1. Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, MD, United States;2. Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, MD, United States;3. Department of Orthopedic Surgery, Stanford Medicine, Stanford, CA, United States;4. Department of Neurological Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH, United States;1. Department of Gastroenterology, Lebanese University, Beirut, Lebanon;2. Department of Internal Medicine, Lebanese University, Beirut, Lebanon;3. Department of Gastroenterology, Beirut Arab University, Beirut, Lebanon;4. Department of Internal Medicine, American University of Beirut, Beirut, Lebanon;5. Department of Gastroenterology, Lille Catholic University, Lille, France |
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| Abstract: | The effects of 8-week treatment with oral histamine H2-antagonists (ranitidine or cimetidine) or an antacid on plasma levels of histamine and serotonin were studied in duodenal ulcer patients. Histamine H2-antagonists significantly elevated plasma histamine levels, however, they markedly decreased serotonin concentrations by the 4th week of treatment. Antacid treatment similarly increased histamine levels without significantly affecting blood serotonin. It is concluded that changes in intragastric or intraduodenal acidity affect histamine release, as reflected by increased blood levels; serotonin secretion could be influenced by blocking histamine H2-receptors, possibly those located mainly in the gastrointestinal tract. |
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