三阴性乳腺癌临床病理特征及预后分析

目的了解三阴性乳腺癌（TNBC）临床病理特征及其预后。方法收集我科手术切除并经病理证实的465例原发性乳腺癌的临床病理资料，根据ER、PR及Her-2蛋白免疫组化表达分为两类：TNBC和非TNBC，并随访其预后情况，比较两类乳腺癌临床病理特征及预后的差异。结果TNBC有73例，占15．7％，多见于50岁前未绝经女性，随访369例中复发转移39例，TNBC复发转移率（18．3％，11／60）高于非TNBC（9．1％，28／309，P=0．033）。结论TNBC患者发病年龄较早，易发生复发转移，预后较差。

Pathological characteristics and prognosis of triple-negative breast cancer

Objective To explore the pathological characteristics and prognosis of triple-negative breast cancer(TNBC).Methods The pathological data of 465 cases of operable primary breast cancer were analyzed.TNBC was immunohistochemically defined by a lack of expression of ER,PR and Her-2.The differences of pathological characteristics and prognosis between TNBC and non-TNBC were explored.Results TNBC count for about 15%(73/465)of all breast carcinomas.TNBC correlated with younger(＜50y)and premenopausal women (P＜0.05).The follow-up time of the 369 cases was truncated at January 2009,and 39 cases had recurrence or metastasis,the relapse rate of TNBC(18.3%,11/60)was higher than that of non-TNBC(9.1%,28/309,P=0.033).Conclusions The patients with TNBC were younger,and had an increased likelihood of relapse.