The importance of the production of phosphatidic acid for the release of arachidonic acid in stimulated platelets |
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Authors: | Eduardo G Lapetina M Motasim Billah |
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Institution: | (1) Department of Molecular Biology, The Wellcome Research Laboratories, 27709 Research Triangle Park, N.C., USA |
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Abstract: | Phosphatidic acid is formed by platelets as a result of the combined activities of phospholipase C and diacylglycerol kinase. The initial thrombin-activated phospholipase C-mediated reaction is quinacrine insensitive and is followed by quinacrine-sensitive phospholipase A2 activities. The phosphatidic acid released probably results in cellular calcium gating, which among other actions, might release arachidonic acid by activating phospholipases A2: Indeed, we have detected a phosphatidic acid-specific phospholipase A2 in platelets, which might have an important role in the liberation of arachidonic acid. |
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