| 中药石菖蒲对脑内单胺类神经递质5-羟色胺水平的影响 |
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| 引用本文： | 谢婷婷,王虹,刘屏,王东晓.中药石菖蒲对脑内单胺类神经递质5-羟色胺水平的影响[J].中国药物应用与监测,2007,4(3):15-17. |
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| 作者姓名： | 谢婷婷 王虹 刘屏 王东晓 |
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| 作者单位： | 解放军总医院药理研究室,北京,100853 |
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| 摘 要： | 目的:观察石菖蒲各提取部分对小鼠大脑内5-羟色胺(5-HT)含量的影响。方法:通过给小鼠灌服石菖蒲不同提取部分,用高效液相色谱-电化学检测法分别测定小鼠大脑内5-HT的含量,研究石菖蒲各提取部分对5-HT含量的影响。结果:小鼠灌服石菖蒲后大脑内5-HT的含量变化如下:石菖蒲挥发油组,石菖蒲水煎液及全方组5-HT的含量均比空白组显著升高(P<0.05,P<0.01,P<0.01)。结论:石菖蒲可显著增加小鼠大脑内5-羟色胺的含量,以此推测石菖蒲很可能通过上调脑内5-HT水平,促进血脑屏障的开放。
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| 关 键 词： | 石菖蒲 5-羟色胺 血脑屏障 |
| 文章编号： | 1672-8157(2007)03-0015-03 |
| 修稿时间： | 2006年12月11 |
The influence of Acorus tatarinowii Schott on level of 5-hydroxytryptamine in brain |
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| Authors: | XIE Ting-ting WANG Hong LIU Ping |
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| Abstract: | Objective:To observe the effect of Acorus tatarinowii Schott on level of 5-hydroxytryptamine (5-HT) in mice's brain.Methods:The levels of 5-HT in mice's brain were determined after po with different components of Acorus tatarinowii Schott by high performance liquid chromatography with electrochemical detection (HPLC-ECD), and the Acorus tatarinowii Schott's effect on the levels of 5-HT was studied.Results:The level of 5-HT in mice's brain after administration of naphtha were increased significantly compared to blank group(P>0.05, P>0.01, P>0.01).Conclusion:Acorus tatarinowii Schott could increase the content of 5-HT,and it was possible to promote the open of blood-brain barrier. |
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| Keywords: | Acorus tatarinowii Schott 5-Hydroxytryptamine Blood-brain barrier |
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