葡萄糖酸亚铁治疗小儿反复呼吸道感染疗效观察

目的: 探讨铁剂治疗对反复呼吸道感染(RRTI)的防治作用。方法: 将符合1987年全国小儿呼吸道疾病学术会议通过的反复呼吸道感染诊断标准并伴缺铁性贫血的108例患儿,随机分为治疗组68例及对照组40例,治疗组在常规治疗基础上加用葡萄糖酸亚铁治疗,对照组在常规治疗基础上未使用其它治疗。检测两组治疗前后血清免疫球蛋白含量变化并评估疗效。结果: 治疗后治疗组血清IgG、IgA含量均较对照组明显增加(P<0.001)。治疗组总有效率71.19%,对照组为32.35%,两组比较差异有显著性(P<0.005)。结论: 铁缺乏在RRTI发生发展中具有重要意义,对RRTI患儿常规检测铁,对铁缺乏者适当补充铁剂,有利于RRTI的治疗。

Observations on the effect of ferrous gluconate on children with RRTI

Objective:To study the clinical effect of ferrous gluconate on children with recurrent respiratory tract infections(RRTI).Methods:One hundred and eight children with RRTI and iron deficiency anemia(IDA) were divided into two groups.The observation group were given ferrous gluconate on the basis of routine therapy and the control group were treated by routine therapy.Serum specimens were collected before and after the treatment.IgG,IgA,IgM were determined by scattered nephelometry and the curative effect was evaluated.Results:The levels of serum IgG,IgA in the observation group were higher than that of the controls( P <0.001).The response rate in the observation group was higher than that in the control group(71.19% vs 32.35%)( P < 0.005 ).Conclusions:Iron deficiency is highly related to the development of RRTI in children.To determine the iron concentration and to replenish iron preparation is beneifcial to the treatment of children with RRTI.