Involvement of mitogen-activated protein kinase in peroxynitrite-induced cell death of human neuroblastoma SH-SY5Y cells |
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Authors: | Saeki M Kamisaki Y Maeda S |
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Affiliation: | Department of Pharmacology, Faculty of Dentistry, Osaka University, Suita, 1-8 Yamadaoka, Osaka 565-0871, Japan. |
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Abstract: | We have investigated the activation of mitogen-activated protein kinase (MAP kinase) in relation to cell death induced by peroxynitrite in human neuroblastoma SH-SY5Y cells. Exposure of the cells to peroxynitrite caused transient increase in MAP kinase activity, and resulted in cell death. PD98059, a selective inhibitor of MAP kinase kinase, reduced peroxynitrite-induced cell death. These results suggest that the activation of MAP kinase may be involved in cell death induced by peroxynitrite. |
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