| RASSF1A基因甲基化与非小细胞肺癌预后的相关性研究 |
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| 引用本文： | 张卉,张树才,张宗德,贾红彦,古淑香,赵丹.RASSF1A基因甲基化与非小细胞肺癌预后的相关性研究[J].中国肺癌杂志,2010,13(4). |
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| 作者姓名： | 张卉 张树才 张宗德 贾红彦 古淑香 赵丹 |
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| 作者单位： | 北京胸科医院肿瘤内科,北京,101149 |
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| 摘 要： | 背景与目的研究发现在很多肿瘤中均存在RASSF1A基因启动子区域高甲基化状态导致基因表达失活的现象,本研究就RASSF1A基因启动子的甲基化状态与非小细胞肺癌预后的关系进行探讨。方法采用甲基化特异的PCR检测150例非小细胞肺癌和20例肺部良性病变RASSF1A启动子甲基化状态。结果150例非小细胞肺癌中58例发现RASSF1A启动子存在甲基化(58/158,38.7%),20例肺部良性病变中无一例发现RASSF1A启动子甲基化。存在RASSF1A启动子高甲基化的病例预后较未发现RASSF1A甲基化的病例差(P=0.004),Cox回归分析显示RASSF1A启动子的甲基化状态是非小细胞肺癌术后的一个预后相关因素(RR=1.584,95%CI:1.040-2.411,P=0.032)。结论MSP法检测RASSF1A启动子甲基化状态可以作为非小细胞肺癌术后的一个预后评价指标。
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| 关 键 词： | 肺肿瘤 甲基化 预后 |
Prognostic Value of Methylation Status of RASSF1A Gene as an Independent Factor of Non-small Cell Lung Cancer |
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| Hui ZHANG,Shucai ZHANG,Zongde ZHANG,Hongyan JIA,Shuxiang GU,Dan ZHAO.Prognostic Value of Methylation Status of RASSF1A Gene as an Independent Factor of Non-small Cell Lung Cancer[J].Chinese Journal of Lung Cancer,2010,13(4). |
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| Authors: | Hui ZHANG Shucai ZHANG Zongde ZHANG Hongyan JIA Shuxiang GU Dan ZHAO |
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| Institution: | Hui ZHANG,Shucai ZHANG,Zongde ZHANG,Hongyan JIA,Shuxiang GU,Dan ZHAO Department of Medical Oncology,Beijing Chest Hospital,Beijing 101149,China |
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| Abstract: | Background and objective Promoter hypermethylation of the RASSF1A gene is among the most abundant epigenetic deregulations in human cancer.The aim of this study is to investigate the relationship between the methylation status of RASSF1A promoter and the prognoses of non-small cell lung cancer (NSCLC).Methods The methylation status of RASSF1A promoter in 150 NSCLC and 25 non-malignant tissues was determined using a methylation-specific polymerase chain reaction (MSP).Results RASSF1A promoter hypermethylatio... |
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| Keywords: | Lung neoplasms Methylation Prognosis |
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