益母草注射液对DIC大鼠血液动力学的影响

目的：探讨益母草注射液（LHS）对弥散性血管内凝血（DIC）大鼠血液动力学的干预作用。方法：静脉注射高分子右旋糖酐（Dextran500）复制大鼠实验性DIC模型。随机分为LHS治疗组、生理盐水治疗组（NS组）和DIC模型组。采用肠系膜微循环观察、器官微区血流和血液流变学测定方法进行研究。结果：大鼠静脉注射Dextran500后，微血管收缩、微血流变慢和微血栓形成；经LHS治疗后，微血管明显扩张，其流态和微血栓积分值低于NS组（P〈0．05）；LHS和NS均能改善胃、肠、肝的微区血流量，但LHS组效果优于NS组（P〈0．05）；LHS还可使血黏度、血小板黏附率和聚集率降低。红细胞变形能力增强。结论：LHS通过扩张微血管、增加器官血流量、降低血黏度和抑制血小板聚集。对DIC具有治疗作用。

Effects of Leonurus Heterophyllus Solution on Hemodynamics in DIC Rats

Objective: To explore the effect of leonurus heterophyllus solution (LHS) on blood dynamics in disseminated intravascular coagulation (DIC) rats. Methods: DIC models were made by Dextran 500 injection and studied by mesenteric microcirculation, determination of hemorheology and blood flow volume. Results: Micro-vessels contraction, slow micro-blood flow and micro-thrombus were observed after Dextran 500 injection. Micro-vessels dilated obviously after LHS treatment and score values of blood flow and micro-thrombus were significantly lower than those in normal saline (NS) treated group (P < 0.05). The micro-area blood flow volume of stomach, intestine and liver increased in LHS and NS groups, and the effect of former was superior to that of NS group (P < 0.05). LHS could reduce the blood viscosity and inhibit platelet aggregation and increase the deformity ability of RBC. Conclusion: LHS can efficiently treat DIC through the micro-vessel dilating, organ blood flow volume increasing, blood viscosity reducing and platelet aggregation inhibiting.