兔鼻源性急性鼻窦炎动物模型

目的：建立一种鼻源性急性鼻窦炎动物模型。方法：将32只新西兰大白兔随机分成A组：单纯膨胀海绵条阻塞鼻腔（10只）；B组：浸有金黄色葡萄球菌的膨胀海绵条阻塞鼻腔（10只）；C组：鼻腔滴注金黄色葡萄球菌菌液不阻塞鼻腔（6只）；D组：空白对照组（6只）。术后2周打开上颌窦，用内镜观察，并取出上颌窦、筛窦黏膜标本分别进行细菌学培养及组织病理学检查。结果：各实验组鼻窦炎模型成功率：A组60％，B组100％，C、D组均0。感染的鼻窦除上颌窦外还累及筛窦。结论：用浸有金黄色葡萄球菌的膨胀海绵条阻塞鼻腔能建立鼻窦炎动物模型，该方法简便易行、无创、成功率高，所引起的鼻窦炎是一种鼻源性鼻窦炎，接近人鼻窦炎的发病机制，更适合有关FESS的研究。

The methods of establishing rhinogenic model of acute sinusitis in the rabbit

Objective:To create a rhinogenic model of acute sinusitis in the rabbits.Method:Thirty-two New Zealand white rabbits were divided into four groups:A group(nasal cavity-implanted with synthetic sponge),B group(nasal cavity-implanted with synthetic sponge and bacteria inoculation),C group(bacteria inoculation group),D group(control).The animals were examined by the methods of endoscope,histology and bacteriology after two weeks.Result:The success rate of model were 60%(A group),100%(B group)and 0%(C,D group).Both maxillary sinus and ethmoid sinus had developed inflammation.Conclusion:A rhinogenic model of acute sinusitis can be created by inserting synthetic sponge instilled with pathogenic bacteria into nasal cavity.This is a simple method and has the potential to be valuable to study on FESS.