糖肾平胶囊对糖尿病小鼠大血管基因表达的影响 |
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引用本文: | 王兴,任敏,徐思,郝晓锋. 糖肾平胶囊对糖尿病小鼠大血管基因表达的影响[J]. 中国天然药物, 2005, 3(1): 53-55 |
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作者姓名: | 王兴 任敏 徐思 郝晓锋 |
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作者单位: | 1. 成都康弘制药有限公司博士后科研工作站,成都,610041 2. 康弘集团·成都法玛基因科技有限公司,成都,610036 |
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基金项目: | 国家863计划新药筛选技术平台研究(No2002AA2Z343E)资助~~ |
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摘 要: | 目的:研究糖肾平胶囊作用于糖尿病小鼠后对大血管基因表达的影响。方法:用高脂高糖饲料诱发C57BL/6J小鼠Ⅱ型糖尿病模型,口服给予糖肾平浸膏粉后提取大血管mRNA,与基因芯片进行杂交,经扫描,计算机软件分析后观察基因表达的变化。结果:找到大血管中相关表达基因。结论:基因芯片有助于研究中药的作用机理,但对所获信息的分析存在一定的难度。
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关 键 词: | 糖肾平 糖尿病 小鼠 大血管 基因表达 基因芯片 |
文章编号: | 1672-3651(2005)01-0000-03 |
修稿时间: | 2004-09-03 |
The Influence of Tangshen Ping Capsules on gene expression of the Big Blood Vessel of Diabetic Mice |
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Abstract: | AIM:To study the influence of Tangshenping capsules on gene expression of the big blood vessel of diabetes mice.METHOD:C57BL/6J mice were fed on conventional chow or diets in high fat and sugar to induce NIDDM model.To extract mRNA from target tissue after taking Tangshenping extract orally.They were hybridized with Oligo microarray and screened through the analysis of gene expression profile.RESULT:The interrelated expression gene in big blood vessel was found.CONCLUSIOIN:Genechip can help to study the function mechanism of the Chinese Medicine,but it is hard to analyze the message acquired. |
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Keywords: | Tangshenping Diabetes Mice Big blood vessel Gene expression |
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